Intercellular Communication
Our research focuses on intercellular communication: how growth factor signaling pathways regulate brain development, and how these pathways contribute to abnormal proliferation, migration and survival in brain tumors and in other neurologic disorders.
Publications View
Developmental basis of SHH medulloblastoma heterogeneity.
Authors: Authors: Gold MP, Ong W, Masteller AM, Ghasemi DR, Galindo JA, Park NR, Huynh NC, Donde A, Pister V, Saurez RA, Vladoiu MC, Hwang GH, Eisemann T, Donovan LK, Walker AD, Benetatos J, Dufour C, Garzia L, Segal RA, Wechsler-Reya RJ, Mesirov JP, Korshunov A, Pajtler KW, Pomeroy SL, Ayrault O, Davidson SM, Cotter JA, Taylor MD, Fraenkel E.
Nat Commun
View full abstract on Pubmed
Nat Commun
View full abstract on Pubmed
TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.
Authors: Authors: Akula SK, Marciano JH, Lim Y, Exposito-Alonso D, Hylton NK, Hwang GH, Neil JE, Dominado N, Bunton-Stasyshyn RK, Song JHT, Talukdar M, Schmid A, Teboul L, Mo A, Shin T, Finander B, Beck SG, Yeh RC, Otani A, Qian X, DeGennaro EM, Alkuraya FS, Maddirevula S, Cascino GD, Giannini C, Burrage LC, Rosenfield JA, Ketkar S, Clark GD, Bacino C, Lewis RA, Segal RA, Bazan JF, Smith KA, Golden JA, Cho G, Walsh CA.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN.
Authors: Authors: Li Y, Pazyra-Murphy MF, Avizonis D, de Sá Tavares Russo M, Tang S, Chen CY, Hsueh YP, Bergholz JS, Jiang T, Zhao JJ, Zhu J, Ko KW, Milbrandt J, DiAntonio A, Segal RA.
J Cell Biol
View full abstract on Pubmed
J Cell Biol
View full abstract on Pubmed
Diversity of developing peripheral glia revealed by single-cell RNA sequencing.
Authors: Authors: Tasdemir-Yilmaz OE, Druckenbrod NR, Olukoya OO, Dong W, Yung AR, Bastille I, Pazyra-Murphy MF, Sitko AA, Hale EB, Vigneau S, Gimelbrant AA, Kharchenko PV, Goodrich LV, Segal RA.
Dev Cell
View full abstract on Pubmed
Dev Cell
View full abstract on Pubmed
Uncomfortably numb: how Nav1.7 mediates paclitaxel-induced peripheral neuropathy.
The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors.
Authors: Authors: Merk DJ, Zhou P, Cohen SM, Pazyra-Murphy MF, Hwang GH, Rehm KJ, Alfaro J, Reid CM, Zhao X, Park E, Xu PX, Chan JA, Eck MJ, Nazemi KJ, Harwell CC, Segal RA.
Dev Neurosci
View full abstract on Pubmed
Dev Neurosci
View full abstract on Pubmed
Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
Authors: Authors: Fukuda Y, Pazyra-Murphy MF, Silagi ES, Tasdemir-Yilmaz OE, Li Y, Rose L, Yeoh ZC, Vangos NE, Geffken EA, Seo HS, Adelmant G, Bird GH, Walensky LD, Marto JA, Dhe-Paganon S, Segal RA.
J Cell Biol
View full abstract on Pubmed
J Cell Biol
View full abstract on Pubmed
Understanding The Epigenetic Landscape and Cellular Architecture of Childhood Brain Tumors.
Authors: Authors: Veiga Cruzeiro GA, Rota C, Hack OA, Segal R, Filbin MG.
Neurochem Int
View full abstract on Pubmed
Neurochem Int
View full abstract on Pubmed
Recognizing Team Science Contributions in Academic Hiring, Promotion, and Tenure.
Authors: Authors: Cline H, Coolen L, de Vries S, Hyman S, Segal R, Steward O.
J Neurosci
View full abstract on Pubmed
J Neurosci
View full abstract on Pubmed
An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development.