Clay Reid, M.D., Ph.D.

Visiting Scientist in Neurobiology
  • Reid Lab
  • 617/432-3621

We study the general question of how visual information is transformed between the lateral geniculate nu-cleus of the thalamus (LGN) and layer 4 of the primary visual cortex. LGN cells receive visual input from one eye and are not sensitive to an object's orientation or direction of movement. Cortical cells often receive binocular inputs and are usually orientation and direction selective. We use a number of techniques to explore how these transformations come about.

In our electrophysiological studies, we record the activity of many individual neurons simultaneously in both thalamus and cortex. In the cat, we are studying the cortical mechanisms responsible for the selectivity for orientation and direction of motion in simple cells. In the macaque, we concentrate on the first stages of color processing in the cortex. We have found that the wiring of the direct inputs to cortex is extremely precise. Given the visual properties of any single layer 4 cortical neuron, virtually all of the thalamic neurons that would help it perform this function are directly connected to it. In order to study the facilitatory interactions between these multiple inputs to cortical neurons, we are currently using multielectrode arrays to record up to ten neurons in the thalamus along with several of their potential targets.

In related projects we are using optical imaging, a technique for mapping the function of neural populations in vivo. These studies produce maps of the visual cortex that show the clustering of neurons with different receptive field properties. Functional maps allow us to target specific types of neurons (such as color-selective cells in the macaque) for electrophysiological study.

Cortical cells often receive binocular inputs and are usually orientation and direction selective. We use a number of techniques to explore how these transformations come about.

  1. Andermann ML, Gilfoy NB, Goldey GJ, Sachdev RN, Wölfel M, McCormick DA, Reid RC, Levene MJ. Chronic cellular imaging of entire cortical columns in awake mice using microprisms. October 17, 2013. Neuron.

    Link to Abstract
  2. Glickfeld LL, Reid RC, Andermann ML. A mouse model of higher visual cortical function. September 8, 2013. Current opinion in neurobiology.

    Link to Abstract
  3. Glickfeld LL, Andermann ML, Bonin V, Reid RC. Cortico-cortical projections in mouse visual cortex are functionally target specific. January 6, 2013. Nature neuroscience.

    Link to Abstract
  4. Reid RC. From functional architecture to functional connectomics. July 26, 2012. Neuron.

    Link to Abstract
  5. William CM, Andermann ML, Goldey GJ, Roumis DK, Reid RC, Shatz CJ, Albers MW, Frosch MP, Hyman BT. Synaptic plasticity defect following visual deprivation in Alzheimer's disease model transgenic mice. June 6, 2012. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  6. Andermann ML, Kerlin AM, Roumis DK, Glickfeld LL, Reid RC. Functional specialization of mouse higher visual cortical areas. December 22, 2011. Neuron.

    Link to Abstract
  7. Bonin V, Histed MH, Yurgenson S, Reid RC. Local diversity and fine-scale organization of receptive fields in mouse visual cortex. December 14, 2011. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  8. Kleinfeld D, Bharioke A, Blinder P, Bock DD, Briggman KL, Chklovskii DB, Denk W, Helmstaedter M, Kaufhold JP, Lee WC, Meyer HS, Micheva KD, Oberlaender M, Prohaska S, Reid RC, Smith SJ, Takemura S, Tsai PS, Sakmann B. Large-scale automated histology in the pursuit of connectomes. November 9, 2011. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  9. Jaume S, Knobe K, Newton RR, Schlimbach F, Blower M, Reid RC. A multiscale parallel computing architecture for automated segmentation of the brain connectome. September 15, 2011. IEEE transactions on bio-medical engineering.

    Link to Abstract
  10. Lee WC, Reid RC. Specificity and randomness: structure-function relationships in neural circuits. August 18, 2011. Current opinion in neurobiology.

    Link to Abstract
  11. Bock DD, Lee WC, Kerlin AM, Andermann ML, Hood G, Wetzel AW, Yurgenson S, Soucy ER, Kim HS, Reid RC. Network anatomy and in vivo physiology of visual cortical neurons. March 10, 2011. Nature.

    Link to Abstract
  12. Akselrod-Ballin A, Bock D, Reid RC, Warfield SK. Accelerating image registration with the Johnson-Lindenstrauss lemma: application to imaging 3-D neural ultrastructure with electron microscopy. March 10, 2011. IEEE transactions on medical imaging.

    Link to Abstract
  13. Kerlin AM, Andermann ML, Berezovskii VK, Reid RC. Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex. September 9, 2010. Neuron.

    Link to Abstract
  14. Ch'ng YH, Reid RC. Cellular imaging of visual cortex reveals the spatial and functional organization of spontaneous activity. August 19, 2010. Frontiers in integrative neuroscience.

    Link to Abstract
  15. Andermann ML, Kerlin AM, Reid RC. Chronic cellular imaging of mouse visual cortex during operant behavior and passive viewing. March 12, 2010. Frontiers in cellular neuroscience.

    Link to Abstract
  16. Histed MH, Bonin V, Reid RC. Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation. August 27, 2009. Neuron.

    Link to Abstract
  17. Pezaris JS, Reid RC. Simulations of electrode placement for a thalamic visual prosthesis. January 1, 2009. IEEE transactions on bio-medical engineering.

    Link to Abstract
  18. Akselrod-Ballin A, Bock D, Reid RC, Warfield SK. Accelerating feature based registration using the Johnson-Lindenstrauss Lemma. January 1, 2009. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention.

    Link to Abstract
  19. Ohki K, Reid RC. Specificity and randomness in the visual cortex. August 27, 2007. Current opinion in neurobiology.

    Link to Abstract
  20. Mrsic-Flogel TD, Hofer SB, Ohki K, Reid RC, Bonhoeffer T, Hübener M. Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity. June 21, 2007. Neuron.

    Link to Abstract
  21. Pezaris JS, Reid RC. Demonstration of artificial visual percepts generated through thalamic microstimulation. April 23, 2007. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  22. Dauguet J, Bock D, Reid RC, Warfield SK. Alignment of large image series using cubic B-splines tessellation: application to transmission electron microscopy data. January 1, 2007. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention.

    Link to Abstract
  23. Ohki K, Chung S, Kara P, Hübener M, Bonhoeffer T, Reid RC. Highly ordered arrangement of single neurons in orientation pinwheels. August 13, 2006. Nature.

    Link to Abstract
  24. McAdams CJ, Reid RC. Attention modulates the responses of simple cells in monkey primary visual cortex. November 23, 2005. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  25. Zhang Y, Reid RC. Single-neuron responses and neuronal decisions in a vernier task. February 22, 2005. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  26. Martinez LM, Wang Q, Reid RC, Pillai C, Alonso JM, Sommer FT, Hirsch JA. Receptive field structure varies with layer in the primary visual cortex. February 13, 2005. Nature neuroscience.

    Link to Abstract
  27. Ohki K, Chung S, Ch'ng YH, Kara P, Reid RC. Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex. January 19, 2005. Nature.

    Link to Abstract
  28. Kara P, Reid RC. Efficacy of retinal spikes in driving cortical responses. September 17, 2003. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  29. Kanold PO, Kara P, Reid RC, Shatz CJ. Role of subplate neurons in functional maturation of visual cortical columns. July 25, 2003. Science (New York, N.Y.).

    Link to Abstract
  30. Kara P, Pezaris JS, Yurgenson S, Reid RC. The spatial receptive field of thalamic inputs to single cortical simple cells revealed by the interaction of visual and electrical stimulation. December 2, 2002. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  31. Reppas JB, Usrey WM, Reid RC. Saccadic eye movements modulate visual responses in the lateral geniculate nucleus. August 29, 2002. Neuron.

    Link to Abstract
  32. Reinagel P, Reid RC. Precise firing events are conserved across neurons. August 15, 2002. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  33. Reid RC, Shapley RM. Space and time maps of cone photoreceptor signals in macaque lateral geniculate nucleus. July 15, 2002. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  34. Martinez LM, Alonso JM, Reid RC, Hirsch JA. Laminar processing of stimulus orientation in cat visual cortex. April 1, 2002. The Journal of physiology.

    Link to Abstract
  35. Reid RC. Divergence and reconvergence: multielectrode analysis of feedforward connections in the visual system. January 1, 2001. Progress in brain research.

    Link to Abstract
  36. Kara P, Reinagel P, Reid RC. Low response variability in simultaneously recorded retinal, thalamic, and cortical neurons. September 1, 2000. Neuron.

    Link to Abstract
  37. Reinagel P, Reid RC. Temporal coding of visual information in the thalamus. July 15, 2000. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  38. Tavazoie SF, Reid RC. Diverse receptive fields in the lateral geniculate nucleus during thalamocortical development. June 1, 2000. Nature neuroscience.

    Link to Abstract
  39. Usrey WM, Reid RC. Visual physiology of the lateral geniculate nucleus in two species of new world monkey: Saimiri sciureus and Aotus trivirgatis. March 15, 2000. The Journal of physiology.

    Link to Abstract
  40. Usrey WM, Reppas JB, Reid RC. Specificity and strength of retinogeniculate connections. December 1, 1999. Journal of neurophysiology.

    Link to Abstract
  41. Usrey WM, Reid RC. Synchronous activity in the visual system. January 1, 1999. Annual review of physiology.

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  42. Dan Y, Alonso JM, Usrey WM, Reid RC. Coding of visual information by precisely correlated spikes in the lateral geniculate nucleus. October 1, 1998. Nature neuroscience.

    Link to Abstract
  43. Usrey WM, Reppas JB, Reid RC. Paired-spike interactions and synaptic efficacy of retinal inputs to the thalamus. September 24, 1998. Nature.

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  44. Reid RC, Alonso JM. The processing and encoding of information in the visual cortex. August 1, 1996. Current opinion in neurobiology.

    Link to Abstract

Harvard Medical SchoolDept of Neurobiology, Goldenson 1-243220 Longwood Ave Boston MA 02115