Clay Reid, M.D., Ph.D.
Professor of Neurobiology
- Reid Lab
We study the general question of how visual information is transformed between the lateral geniculate nu-cleus of the thalamus (LGN) and layer 4 of the primary visual cortex. LGN cells receive visual input from one eye and are not sensitive to an object's orientation or direction of movement. Cortical cells often receive binocular inputs and are usually orientation and direction selective. We use a number of techniques to explore how these transformations come about.
In our electrophysiological studies, we record the activity of many individual neurons simultaneously in both thalamus and cortex. In the cat, we are studying the cortical mechanisms responsible for the selectivity for orientation and direction of motion in simple cells. In the macaque, we concentrate on the first stages of color processing in the cortex. We have found that the wiring of the direct inputs to cortex is extremely precise. Given the visual properties of any single layer 4 cortical neuron, virtually all of the thalamic neurons that would help it perform this function are directly connected to it. In order to study the facilitatory interactions between these multiple inputs to cortical neurons, we are currently using multielectrode arrays to record up to ten neurons in the thalamus along with several of their potential targets.
In related projects we are using optical imaging, a technique for mapping the function of neural populations in vivo. These studies produce maps of the visual cortex that show the clustering of neurons with different receptive field properties. Functional maps allow us to target specific types of neurons (such as color-selective cells in the macaque) for electrophysiological study.
Chronic cellular imaging of entire cortical columns in awake mice using microprisms. October 17, 2013. Neuron.
Cortico-cortical projections in mouse visual cortex are functionally target specific. January 6, 2013. Nature neuroscience.
From functional architecture to functional connectomics. July 26, 2012. Neuron.
Synaptic plasticity defect following visual deprivation in Alzheimer's disease model transgenic mice. June 6, 2012. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Functional specialization of mouse higher visual cortical areas. December 22, 2011. Neuron.
Local diversity and fine-scale organization of receptive fields in mouse visual cortex. December 14, 2011. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Large-scale automated histology in the pursuit of connectomes. November 9, 2011. The Journal of neuroscience : the official journal of the Society for Neuroscience.
A multiscale parallel computing architecture for automated segmentation of the brain connectome. September 15, 2011. IEEE transactions on bio-medical engineering.
Specificity and randomness: structure-function relationships in neural circuits. August 18, 2011. Current opinion in neurobiology.
Network anatomy and in vivo physiology of visual cortical neurons. March 10, 2011. Nature.
Accelerating image registration with the Johnson-Lindenstrauss lemma: application to imaging 3-D neural ultrastructure with electron microscopy. March 10, 2011. IEEE transactions on medical imaging.
Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex. September 9, 2010. Neuron.
Cellular imaging of visual cortex reveals the spatial and functional organization of spontaneous activity. August 19, 2010. Frontiers in integrative neuroscience.
Chronic cellular imaging of mouse visual cortex during operant behavior and passive viewing. March 12, 2010. Frontiers in cellular neuroscience.
Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation. August 27, 2009. Neuron.
Specificity and randomness in the visual cortex. August 27, 2007. Current opinion in neurobiology.
Homeostatic regulation of eye-specific responses in visual cortex during ocular dominance plasticity. June 21, 2007. Neuron.
Demonstration of artificial visual percepts generated through thalamic microstimulation. April 23, 2007. Proceedings of the National Academy of Sciences of the United States of America.
Alignment of large image series using cubic B-splines tessellation: application to transmission electron microscopy data. January 1, 2007. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention.
Highly ordered arrangement of single neurons in orientation pinwheels. August 13, 2006. Nature.
Attention modulates the responses of simple cells in monkey primary visual cortex. November 23, 2005. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Single-neuron responses and neuronal decisions in a vernier task. February 22, 2005. Proceedings of the National Academy of Sciences of the United States of America.
Receptive field structure varies with layer in the primary visual cortex. February 13, 2005. Nature neuroscience.
Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex. January 19, 2005. Nature.
Efficacy of retinal spikes in driving cortical responses. September 17, 2003. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Role of subplate neurons in functional maturation of visual cortical columns. July 25, 2003. Science (New York, N.Y.).
The spatial receptive field of thalamic inputs to single cortical simple cells revealed by the interaction of visual and electrical stimulation. December 2, 2002. Proceedings of the National Academy of Sciences of the United States of America.
Saccadic eye movements modulate visual responses in the lateral geniculate nucleus. August 29, 2002. Neuron.
Precise firing events are conserved across neurons. August 15, 2002. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Space and time maps of cone photoreceptor signals in macaque lateral geniculate nucleus. July 15, 2002. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Laminar processing of stimulus orientation in cat visual cortex. April 1, 2002. The Journal of physiology.
Divergence and reconvergence: multielectrode analysis of feedforward connections in the visual system. January 1, 2001. Progress in brain research.
Low response variability in simultaneously recorded retinal, thalamic, and cortical neurons. September 1, 2000. Neuron.
Temporal coding of visual information in the thalamus. July 15, 2000. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Diverse receptive fields in the lateral geniculate nucleus during thalamocortical development. June 1, 2000. Nature neuroscience.
Visual physiology of the lateral geniculate nucleus in two species of new world monkey: Saimiri sciureus and Aotus trivirgatis. March 15, 2000. The Journal of physiology.
Specificity and strength of retinogeniculate connections. December 1, 1999. Journal of neurophysiology.
Synchronous activity in the visual system. January 1, 1999. Annual review of physiology.
Coding of visual information by precisely correlated spikes in the lateral geniculate nucleus. October 1, 1998. Nature neuroscience.
Paired-spike interactions and synaptic efficacy of retinal inputs to the thalamus. September 24, 1998. Nature.
The processing and encoding of information in the visual cortex. August 1, 1996. Current opinion in neurobiology.
Harvard Medical SchoolDept of Neurobiology, Goldenson 1-243220 Longwood Ave Boston MA 02115