The Clapham laboratory studies ion channels and calcium signaling.
Sperm BerserKers. October 8, 2013. eLife.
Role of the C-terminal domain in the structure and function of tetrameric sodium channels. September 20, 2013. Nature communications.
Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. September 1, 2013. The Journal of general physiology.
Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. July 22, 2013. Proceedings of the National Academy of Sciences of the United States of America.
The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. July 15, 2013. The Journal of general physiology.
MCU encodes the pore conducting mitochondrial calcium currents. June 4, 2013. eLife.
Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. June 3, 2013. Circulation.
Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. May 28, 2013. Proceedings of the National Academy of Sciences of the United States of America.
Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. March 29, 2013. Proceedings of the National Academy of Sciences of the United States of America.
Rheotaxis guides Mammalian sperm. February 28, 2013. Current biology : CB.
mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na(+) Channels to Adapt to Metabolic State. February 7, 2013. Cell.
Sperm patch-clamp. January 1, 2013. Methods in enzymology.
Analysis of the selectivity filter of the voltage-gated sodium channel NavRh. December 18, 2012. Cell research.
TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes. October 12, 2012. Cell.
Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. October 4, 2012. PloS one.
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. September 28, 2012. Cell.
Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. June 12, 2012. Developmental cell.
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. May 20, 2012. Nature.
Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. April 30, 2012. Proceedings of the National Academy of Sciences of the United States of America.
The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. March 4, 2012. Nature neuroscience.
Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL. January 1, 2012. Nature communications.
The channel kinase, TRPM7, is required for early embryonic development. December 27, 2011. Proceedings of the National Academy of Sciences of the United States of America.
A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. November 22, 2011. Proceedings of the National Academy of Sciences of the United States of America.
POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. November 14, 2011. Proceedings of the National Academy of Sciences of the United States of America.
Melanopsin signalling in mammalian iris and retina. November 2, 2011. Nature.
Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. October 24, 2011. Proceedings of the National Academy of Sciences of the United States of America.
The control of male fertility by spermatozoan ion channels. October 13, 2011. Annual review of physiology.
ATP-activated P2X2 current in mouse spermatozoa. August 10, 2011. Proceedings of the National Academy of Sciences of the United States of America.
Ancestral Ca2+ signaling machinery in early animal and fungal evolution. June 16, 2011. Molecular biology and evolution.
TRPM7, the Mg(2+) inhibited channel and kinase. January 1, 2011. Advances in experimental medicine and biology.
A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. January 1, 2011. Nature communications.
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. September 1, 2010. Pharmacological reviews.
An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1. June 13, 2010. Nature structural & molecular biology.
Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption. June 9, 2010. Nano letters.
TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. April 16, 2010. Cell.
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. October 2, 2009. Science (New York, N.Y.).
Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. August 26, 2009. Proceedings of the National Academy of Sciences of the United States of America.
Essential role for TRPC5 in amygdala function and fear-related behavior. May 15, 2009. Cell.
TRPM1 forms ion channels associated with melanin content in melanocytes. May 12, 2009. Science signaling.
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. May 1, 2009. The Journal of general physiology.
Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. April 16, 2009. Proceedings of the National Academy of Sciences of the United States of America.
A STIMulus Package puts orai calcium channels to work. March 6, 2009. Cell.
Phenotyping sensory nerve endings in vitro in the mouse. January 1, 2009. Nature protocols.
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. October 31, 2008. Science (New York, N.Y.).
Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. October 30, 2008. PloS one.
TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. June 6, 2008. Proceedings of the National Academy of Sciences of the United States of America.
Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. May 7, 2008. PloS one.
Detailed comparison of expressed and native voltage-gated proton channel currents. March 20, 2008. The Journal of physiology.
The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP. March 4, 2008. Molecular and cellular neurosciences.
Ion channels that control fertility in mammalian spermatozoa. January 1, 2008. The International journal of developmental biology.
Calcium signaling. December 14, 2007. Cell.
The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. December 1, 2007. Microbiology (Reading, England).
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. November 7, 2007. Proceedings of the National Academy of Sciences of the United States of America.
CatSperbeta, a novel transmembrane protein in the CatSper channel complex. May 3, 2007. The Journal of biological chemistry.
KSper, a pH-sensitive K+ current that controls sperm membrane potential. April 25, 2007. Proceedings of the National Academy of Sciences of the United States of America.
SnapShot: mammalian TRP channels. April 6, 2007. Cell.
All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. January 16, 2007. Proceedings of the National Academy of Sciences of the United States of America.
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. November 22, 2006. Cell.
The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. November 9, 2006. Neuron.
Bisandrographolide from Andrographis paniculata activates TRPV4 channels. August 9, 2006. The Journal of biological chemistry.
Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. June 8, 2006. The EMBO journal.
CACNA1H mutations in autism spectrum disorders. June 5, 2006. The Journal of biological chemistry.
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. April 16, 2006. Nature neuroscience.
A voltage-gated proton-selective channel lacking the pore domain. March 22, 2006. Nature.
Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. February 9, 2006. Nature.
An introduction to TRP channels. January 1, 2006. Annual review of physiology.
Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. December 15, 2005. Circulation research.
International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. December 1, 2005. Pharmacological reviews.
International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. December 1, 2005. Pharmacological reviews.
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. December 1, 2005. Pharmacological reviews.
Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. September 28, 2005. The Journal of neuroscience : the official journal of the Society for Neuroscience.
TRP channels and mice deficient in TRP channels. August 3, 2005. Pflügers Archiv : European journal of physiology.
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. May 27, 2005. Nature genetics.
TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. April 1, 2005. Molecular and cellular biology.
Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. September 22, 2004. The Journal of neuroscience : the official journal of the Society for Neuroscience.
SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. August 19, 2004. Neuron.
Rapid vesicular translocation and insertion of TRP channels. July 18, 2004. Nature cell biology.
The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. July 8, 2004. Proceedings of the National Academy of Sciences of the United States of America.
TRP ion channels in the nervous system. June 1, 2004. Current opinion in neurobiology.
A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. March 16, 2004. PLoS biology.
The mitochondrial calcium uniporter is a highly selective ion channel. January 22, 2004. Nature.
Intracellular signaling and regulation of cardiac ion channels January 1, 2004. Cardiac Electrophysiology.
Excitability and Conduction January 1, 2004. The Molecular Basis of Heart Disease.
Symmetry, selectivity, and the 2003 Nobel Prize. December 12, 2003. Cell.
A superfamily of voltage-gated sodium channels in bacteria. December 9, 2003. The Journal of biological chemistry.
TRP channels as cellular sensors. December 4, 2003. Nature.
International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. December 1, 2003. Pharmacological reviews.
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. December 1, 2003. Pharmacological reviews.
CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. December 1, 2003. Proceedings of the National Academy of Sciences of the United States of America.
The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. November 13, 2003. Neuron.
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. August 1, 2003. Nature neuroscience.
Formation of novel TRPC channels by complex subunit interactions in embryonic brain. July 11, 2003. The Journal of biological chemistry.
Mechanism of persistent protein kinase D1 translocation and activation. April 1, 2003. Developmental cell.
Real-time imaging of nuclear permeation by EGFP in single intact cells. February 1, 2003. Biophysical journal.
International Union of Pharmacology: Approaches to the nomenclature of voltage-gated ion channels January 1, 2003. Pharmacological Reviews.
Modified herpes simplex virus delivery of enhanced GFP into the central nervous system. December 15, 2002. Journal of neuroscience methods.
The cation selectivity filter of the bacterial sodium channel, NaChBac. December 1, 2002. The Journal of general physiology.
Sorting out MIC, TRP, and CRAC ion channels. August 1, 2002. The Journal of general physiology.
TRPV3 is a calcium-permeable temperature-sensitive cation channel. June 23, 2002. Nature.
The TRPM7 channel is inactivated by PIP(2) hydrolysis. May 1, 2002. Nature cell biology.
Signal transduction. Hot and cold TRP ion channels. March 22, 2002. Science (New York, N.Y.).
Structural characterization of the mouse Girk genes. February 6, 2002. Gene.
A unified nomenclature for the superfamily of TRP cation channels. February 1, 2002. Molecular cell.
G protein-coupled receptor signaling through ion channels January 1, 2002. GPCRs in the CNS- The GPCR Superfamily.
A prokaryotic voltage-gated sodium channel. December 14, 2001. Science (New York, N.Y.).
A voltage-gated ion channel expressed specifically in spermatozoa. October 23, 2001. Proceedings of the National Academy of Sciences of the United States of America.
A sperm ion channel required for sperm motility and male fertility. October 11, 2001. Nature.
In memorium. August 1, 2001. Journal of molecular and cellular cardiology.
Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. June 15, 2001. Journal of the American College of Cardiology.
The TRP ion channel family. June 1, 2001. Nature reviews. Neuroscience.
Two S-adenosylmethionine synthetase-encoding genes differentially expressed during adventitious root development in Pinus contorta. June 1, 2001. Plant molecular biology.
Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway. May 15, 2001. Journal of immunology (Baltimore, Md. : 1950).
CaT1 manifests the pore properties of the calcium-release-activated calcium channel. April 5, 2001. Nature.
TRPC1 and TRPC5 form a novel cation channel in mammalian brain. March 1, 2001. Neuron.
TRP-PLIK, a bifunctional protein with kinase and ion channel activities. January 18, 2001. Science (New York, N.Y.).
The Stoichiometry of Gbeta gamma binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs). January 8, 2001. The Journal of biological chemistry.
How to lose your hippocampus by working on chloride channels. January 1, 2001. Neuron.
Intracellular calcium signaling January 1, 2001. Roger Eckert Memorial Lecture.
Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. November 17, 2000. The Journal of biological chemistry.
A switch mechanism for G beta gamma activation of I(KACh). September 22, 2000. The Journal of biological chemistry.
Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. August 1, 2000. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Distinct ion channel classes are expressed on the outer nuclear envelope of T- and B-lymphocyte cell lines. July 1, 2000. Biophysical journal.
ICln is essential for cellular and early embryonic viability. April 28, 2000. The Journal of biological chemistry.
Tissue-specific expression of Pa18, a putative lipid transfer protein gene, during embryo development in Norway spruce (Picea abies). February 1, 2000. Plant molecular biology.
Remembering Eva Neer January 1, 2000. Cell.
More pieces of the K+ ion channel puzzle. September 1, 1999. Nature structural biology.
Conformational changes of the in situ nuclear pore complex. July 1, 1999. Biophysical journal.
pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. June 1, 1999. Molecular and cellular biology.
Unlocking family secrets: K+ channel transmembrane domains. May 28, 1999. Cell.
Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3. May 15, 1999. The Journal of membrane biology.
Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel. May 1, 1999. Neuron.
Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh. April 30, 1999. Annals of the New York Academy of Sciences.
Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells. February 1, 1999. The Journal of general physiology.
GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. January 22, 1999. The Journal of biological chemistry.
Gbetagamma binding increases the open time of IKACh: kinetic evidence for multiple Gbetagamma binding sites. January 1, 1999. Biophysical journal.
G proteins and ion channels January 1, 1999. Cardiac Electrophysiology.
G-protein-gated potassium channels: Implications for the weaver mouse January 1, 1999. Potassium Ion Channels: Molecular Structure, Function, and Diseases.
Touch channels sense blood pressure. December 1, 1998. Neuron.
Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. October 16, 1998. The Journal of biological chemistry.
Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation. July 3, 1998. The Journal of biological chemistry.
Not so funny anymore: pacing channels are cloned. July 1, 1998. Neuron.
NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation. June 1, 1998. Nature neuroscience.
The list of potential volume-sensitive chloride currents continues to swell (and shrink). May 1, 1998. The Journal of general physiology.
pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. May 1, 1998. The Journal of biological chemistry.
A novel inward rectifier K+ channel with unique pore properties. May 1, 1998. Neuron.
At last, the structure of an ion-selective channel. May 1, 1998. Nature structural biology.
Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel. March 1, 1998. Molecular and cellular biology.
Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh. February 27, 1998. The Journal of biological chemistry.
Calcium regulation of nuclear pore permeability. February 1, 1998. Cell calcium.
Abnormal heart rate regulation in GIRK4 knockout mice. January 1, 1998. Neuron.
Some like it hot: spicing up ion channels. October 23, 1997. Nature.
Nuclear calcium and the regulation of the nuclear pore complex. September 1, 1997. BioEssays : news and reviews in molecular, cellular and developmental biology.
Calcium release and influx colocalize to the endoplasmic reticulum. August 1, 1997. Current biology : CB.
Ion channels--basic science and clinical disease. May 29, 1997. The New England journal of medicine.
Nucleoplasmic and cytoplasmic differences in the fluorescence properties of the calcium indicator Fluo-3. April 1, 1997. Cell calcium.
Partial structure, chromosome localization, and expression of the mouse Icln gene. March 15, 1997. Genomics.
Partial structure, chromosome localization, and expression of the mouse Girk4 gene. March 15, 1997. Genomics.
G protein beta gamma subunits. January 1, 1997. Annual review of pharmacology and toxicology.
The molecular control of cardiac ion channels. January 1, 1997. Heart and vessels.
Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores. September 27, 1996. Science (New York, N.Y.).
Intracellular signalling: more jobs for G beta gamma. July 1, 1996. Current biology : CB.
Nonselective and G betagamma-insensitive weaver K+ channels. June 28, 1996. Science (New York, N.Y.).
A wound-inducible gene from Salix viminalis coding for a trypsin inhibitor. June 1, 1996. Plant molecular biology.
Inward rectification of the IRK1 K+ channel reconstituted in lipid bilayers. June 1, 1996. Biophysical journal.
TRP is cracked but is CRAC TRP? June 1, 1996. Neuron.
Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes. February 1, 1996. Neuron.
The G-protein nanomachine. January 25, 1996. Nature.
The K+ channel inward rectifier subunits form a channel similar to neuronal G protein-gated K+ channel. January 22, 1996. FEBS letters.
Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+ channel subunits. January 1, 1996. Neuropharmacology.
Nuclear ion channels and regulation of the nuclear pore. January 1, 1996. Society of General Physiologists series.
Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs. December 15, 1995. The Biochemical journal.
The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes. December 15, 1995. The Journal of biological chemistry.
Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+ store. December 15, 1995. Science (New York, N.Y.).
G beta gamma binds directly to the G protein-gated K+ channel, IKACh. December 8, 1995. The Journal of biological chemistry.
The cardiac inward rectifier K+ channel subunit, CIR, does not comprise the ATP-sensitive K+ channel, IKATP. December 1, 1995. The Journal of biological chemistry.
Ion channel regulation by G proteins. October 1, 1995. Physiological reviews.
Intracellular calcium. Replenishing the stores. June 22, 1995. Nature.
G-protein regulation of ion channels. June 1, 1995. Current opinion in neurobiology.
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. March 9, 1995. Nature.
Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes. February 1, 1995. Immunology.
Calcium signaling. January 27, 1995. Cell.
Calcium release from the nucleus by InsP3 receptor channels. January 1, 1995. Neuron.
Intracellular calcium waves. January 1, 1995. Advances in second messenger and phosphoprotein research.
Signal transduction. Why testicles are cool. September 8, 1994. Nature.
Calcium channels activated by depletion of internal calcium stores in A431 cells. July 1, 1994. Biophysical journal.
Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. March 17, 1994. Nature.
Molecular characterization of a swelling-induced chloride conductance regulatory protein, pICln. February 11, 1994. Cell.
Hypotonicity activates a native chloride current in Xenopus oocytes. February 1, 1994. The Journal of general physiology.
Simultaneous near ultraviolet and visible excitation confocal microscopy of calcium transients in Xenopus oocytes. January 1, 1994. Methods in cell biology.
Direct G protein activation of ion channels? January 1, 1994. Annual review of neuroscience.
G-protein-mediated pathways assayed by electrophysiology and confocal microscopy. January 1, 1994. Methods in enzymology.
Characterization of a native swelling-induced chloride current, ICl.swell, and its regulatory protein, pICln, in Xenopus oocytes. January 1, 1994. The Japanese journal of physiology.
Mutations in G protein-linked receptors: novel insights on disease. December 31, 1993. Cell.
Confocal imaging system for visible and ultraviolet light November 9, 1993. Confocal imaging system for visible and ultraviolet light.
A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte. October 1, 1993. Biophysical journal.
New roles for G-protein beta gamma-dimers in transmembrane signalling. September 30, 1993. Nature.
Specificity of receptor-G protein interactions: searching for the structure behind the signal. September 1, 1993. Cellular signalling.
Cellular calcium. A mysterious new influx factor? August 26, 1993. Nature.
Reply. July 1, 1993. Trends in cardiovascular medicine.
Alpha-helical distorting substitution disrupt coupling between m3 muscarinic receptor and G proteins. June 7, 1993. FEBS letters.
Calcium waves. June 1, 1993. Current opinion in neurobiology.
Acceleration of intracellular calcium waves in Xenopus oocytes by calcium influx. April 9, 1993. Science (New York, N.Y.).
Calcium wave propagation by calcium-induced calcium release: an unusual excitable system. March 1, 1993. Bulletin of mathematical biology.
Cardiac chloride channels. January 1, 1993. Trends in cardiovascular medicine.
Intracellular waves observed by confocal microscopy from Xenopus oocytes. January 1, 1993. Advances in second messenger and phosphoprotein research.
Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes. April 17, 1992. Cell.
New mammalian chloride channel identified by expression cloning. March 19, 1992. Nature.
Two-dimensional model of calcium waves reproduces the patterns observed in Xenopus oocytes. February 1, 1992. Biophysical journal.
Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca(2+)-permeable channel. January 23, 1992. Nature.
Spiral waves and intracellular calcium signalling. January 1, 1992. Journal of physiology, Paris.
Signal transduction through G proteins in the cardiac myocyte. January 1, 1992. Trends in cardiovascular medicine.
Two novel cardiac atrial K+ channels, IK.AA and IK.PC. November 1, 1991. The Journal of general physiology.
Cloning and expression of a rat cardiac delayed rectifier potassium channel. September 1, 1991. Proceedings of the National Academy of Sciences of the United States of America.
Chloride channels in the nuclear membrane. July 1, 1991. The Journal of membrane biology.
Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors. April 11, 1991. Nature.
Spiral calcium wave propagation and annihilation in Xenopus laevis oocytes. April 5, 1991. Science (New York, N.Y.).
Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. December 1, 1990. The EMBO journal.
Intracellular regulation of ion channels in cell membranes. August 1, 1990. Mayo Clinic proceedings. Mayo Clinic.
Arachidonic acid and its metabolites in the regulation of G-protein gated K+ channels in atrial myocytes. March 1, 1990. Biochemical pharmacology.
A comparison of the roles of purified G protein subunits in the activation of the cardiac muscarinic K+ channel. January 1, 1990. Society of General Physiologists series.
Diverse functions of muscarinic acetylcholine receptor subtypes. December 1, 1989. Trends in pharmacological sciences.
Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells. August 1, 1989. Pflügers Archiv : European journal of physiology.
Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. June 9, 1989. Science (New York, N.Y.).
G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. February 9, 1989. Nature.
G protein activation mechanisms of the cardiac K+ channel, iK.ACh. January 1, 1989. Society of General Physiologists series.
Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. August 1, 1988. Proceedings of the National Academy of Sciences of the United States of America.
Activation of atrial muscarinic-gated K+ channels by beta gamma-subunits of G proteins. June 1, 1988. The American journal of physiology.
Endothelial communication. State of the art lecture. June 1, 1988. Hypertension.
Muscarinic-activated K+ current in bovine aortic endothelial cells. June 1, 1988. Circulation research.
Roles of G protein subunits in transmembrane signalling. May 12, 1988. Nature.
Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line. May 1, 1988. Circulation research.
Haemodynamic shear stress activates a K+ current in vascular endothelial cells. January 14, 1988. Nature.
Delayed rectifier K+ current in embryonic chick heart ventricle. January 1, 1988. The American journal of physiology.
The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. January 1, 1987. Nature.
gamma-Aminobutyric acid receptor channels in adrenal chromaffin cells: a patch-clamp study. April 1, 1985. Proceedings of the National Academy of Sciences of the United States of America.
Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells. August 1, 1984. The Journal of physiology.
Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages. May 1, 1984. Proceedings of the National Academy of Sciences of the United States of America.
Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. February 1, 1984. The Journal of physiology.
Voltage-activated k channels in embryonic chick heart. January 1, 1984. Biophysical journal.
Small signal impedance of heart cell membranes. January 1, 1982. The Journal of membrane biology.
Junctional resistance and action potential delay between embryonic heart cell aggregates. June 1, 1980. The Journal of general physiology.
Development of electrical coupling and action potential synchrony between paired aggregates of embryonic heart cells. December 12, 1979. The Journal of membrane biology.
The theoretical small signal impedance of the frog node, Rana pipiens. November 5, 1976. Pflügers Archiv : European journal of physiology.
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