David Clapham, M.D., PH.D.

Aldo R. Castaneda Professor of Cardiovascular Research
  • Clapham Website
  • Clapham Lab
  • 617/919-2680

The Clapham laboratory studies ion channels and calcium signaling. 

  1. Tsai MF, Jiang D, Zhao L, Clapham D, Miller C. Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1. December 16, 2013. The Journal of general physiology.

    Link to Abstract
  2. Decaen PG, Delling M, Vien TN, Clapham DE. Direct recording and molecular identification of the calcium channel of primary cilia. December 11, 2013. Nature.

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  3. Delling M, Decaen PG, Doerner JF, Febvay S, Clapham DE. Primary cilia are specialized calcium signalling organelles. December 11, 2013. Nature.

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  4. Carvacho I, Lee HC, Fissore RA, Clapham DE. TRPV3 Channels Mediate Strontium-Induced Mouse-Egg Activation. December 5, 2013. Cell reports.

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  5. Clapham DE. The mother of all endocytosis. November 26, 2013. eLife.

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  6. Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE Is an Essential Component of the Mitochondrial Calcium Uniporter Complex. November 14, 2013. Science (New York, N.Y.).

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  7. Clapham DE. Sperm BerserKers. October 8, 2013. eLife.

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  8. Bagnéris C, Decaen PG, Hall BA, Naylor CE, Clapham DE, Kay CW, Wallace BA. Role of the C-terminal domain in the structure and function of tetrameric sodium channels. September 20, 2013. Nature communications.

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  9. Zeng XH, Navarro B, Xia XM, Clapham DE, Lingle CJ. Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa. September 1, 2013. The Journal of general physiology.

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  10. Sah R, Mesirca P, Van den Boogert M, Rosen J, Mably J, Mangoni ME, Clapham DE. Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity. July 22, 2013. Proceedings of the National Academy of Sciences of the United States of America.

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  11. Mesirca P, Marger L, Toyoda F, Rizzetto R, Audoubert M, Dubel S, Torrente AG, Difrancesco ML, Muller JC, Leoni AL, Couette B, Nargeot J, Clapham DE, Wickman K, Mangoni ME. The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation. July 15, 2013. The Journal of general physiology.

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  12. Chaudhuri D, Sancak Y, Mootha VK, Clapham DE. MCU encodes the pore conducting mitochondrial calcium currents. June 4, 2013. eLife.

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  13. Sah R, Mesirca P, Mason X, Gibson W, Bates-Withers C, Van den Boogert M, Chaudhuri D, Pu WT, Mangoni ME, Clapham DE. Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization. June 3, 2013. Circulation.

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  14. Jiang D, Zhao L, Clish CB, Clapham DE. Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome. May 28, 2013. Proceedings of the National Academy of Sciences of the United States of America.

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  15. Ulmschneider MB, Bagnéris C, McCusker EC, Decaen PG, Delling M, Clapham DE, Ulmschneider JP, Wallace BA. Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel. March 29, 2013. Proceedings of the National Academy of Sciences of the United States of America.

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  16. Miki K, Clapham DE. Rheotaxis guides Mammalian sperm. February 28, 2013. Current biology : CB.

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  17. Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na(+) Channels to Adapt to Metabolic State. February 7, 2013. Cell.

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  18. Lishko P, Clapham DE, Navarro B, Kirichok Y. Sperm patch-clamp. January 1, 2013. Methods in enzymology.

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  19. Zhang X, Xia M, Li Y, Liu H, Jiang X, Ren W, Wu J, Decaen P, Yu F, Huang S, He J, Clapham DE, Yan N, Gong H. Analysis of the selectivity filter of the voltage-gated sodium channel NavRh. December 18, 2012. Cell research.

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  20. Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes. October 12, 2012. Cell.

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  21. Stotz SC, Clapham DE. Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen. October 4, 2012. PloS one.

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  22. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. September 28, 2012. Cell.

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  23. Desai BN, Krapivinsky G, Navarro B, Krapivinsky L, Carter BC, Febvay S, Delling M, Penumaka A, Ramsey IS, Manasian Y, Clapham DE. Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis. June 12, 2012. Developmental cell.

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  24. Zhang X, Ren W, DeCaen P, Yan C, Tao X, Tang L, Wang J, Hasegawa K, Kumasaka T, He J, Wang J, Clapham DE, Yan N. Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. May 20, 2012. Nature.

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  25. Kaczmarek JS, Riccio A, Clapham DE. Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse. April 30, 2012. Proceedings of the National Academy of Sciences of the United States of America.

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  26. Wu LJ, Wu G, Akhavan Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. March 4, 2012. Nature neuroscience.

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  27. Doerner JF, Febvay S, Clapham DE. Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL. January 1, 2012. Nature communications.

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  28. Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. The channel kinase, TRPM7, is required for early embryonic development. December 27, 2011. Proceedings of the National Academy of Sciences of the United States of America.

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  29. Clapham DE, Miller C. A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels. November 22, 2011. Proceedings of the National Academy of Sciences of the United States of America.

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  30. Krapivinsky G, Krapivinsky L, Stotz SC, Manasian Y, Clapham DE. POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters. November 14, 2011. Proceedings of the National Academy of Sciences of the United States of America.

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  31. Xue T, Do MT, Riccio A, Jiang Z, Hsieh J, Wang HC, Merbs SL, Welsbie DS, Yoshioka T, Weissgerber P, Stolz S, Flockerzi V, Freichel M, Simon MI, Clapham DE, Yau KW. Melanopsin signalling in mammalian iris and retina. November 2, 2011. Nature.

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  32. Zimmermann K, Lennerz JK, Hein A, Link AS, Kaczmarek JS, Delling M, Uysal S, Pfeifer JD, Riccio A, Clapham DE. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. October 24, 2011. Proceedings of the National Academy of Sciences of the United States of America.

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  33. Lishko PV, Kirichok Y, Ren D, Navarro B, Chung JJ, Clapham DE. The control of male fertility by spermatozoan ion channels. October 13, 2011. Annual review of physiology.

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  34. Navarro B, Miki K, Clapham DE. ATP-activated P2X2 current in mouse spermatozoa. August 10, 2011. Proceedings of the National Academy of Sciences of the United States of America.

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  35. Cai X, Clapham DE. Ancestral Ca2+ signaling machinery in early animal and fungal evolution. June 16, 2011. Molecular biology and evolution.

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  36. Bates-Withers C, Sah R, Clapham DE. TRPM7, the Mg(2+) inhibited channel and kinase. January 1, 2011. Advances in experimental medicine and biology.

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  37. Chung JJ, Navarro B, Krapivinsky G, Krapivinsky L, Clapham DE. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. January 1, 2011. Nature communications.

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  38. Wu LJ, Sweet TB, Clapham DE. International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. September 1, 2010. Pharmacological reviews.

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  39. Ramsey IS, Mokrab Y, Carvacho I, Sands ZA, Sansom MS, Clapham DE. An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1. June 13, 2010. Nature structural & molecular biology.

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  40. Febvay S, Marini DM, Belcher AM, Clapham DE. Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption. June 9, 2010. Nano letters.

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  41. Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, Clapham DE, Xu H. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. April 16, 2010. Cell.

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  42. Jiang D, Zhao L, Clapham DE. Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. October 2, 2009. Science (New York, N.Y.).

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  43. Zhou H, Clapham DE. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. August 26, 2009. Proceedings of the National Academy of Sciences of the United States of America.

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  44. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. May 15, 2009. Cell.

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  45. Oancea E, Vriens J, Brauchi S, Jun J, Splawski I, Clapham DE. TRPM1 forms ion channels associated with melanin content in melanocytes. May 12, 2009. Science signaling.

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  46. Blair NT, Kaczmarek JS, Clapham DE. Intracellular calcium strongly potentiates agonist-activated TRPC5 channels. May 1, 2009. The Journal of general physiology.

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  47. Ramsey IS, Ruchti E, Kaczmarek JS, Clapham DE. Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst. April 16, 2009. Proceedings of the National Academy of Sciences of the United States of America.

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  48. Clapham DE. A STIMulus Package puts orai calcium channels to work. March 6, 2009. Cell.

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  49. Zimmermann K, Hein A, Hager U, Kaczmarek JS, Turnquist BP, Clapham DE, Reeh PW. Phenotyping sensory nerve endings in vitro in the mouse. January 1, 2009. Nature protocols.

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  50. Jin J, Desai BN, Navarro B, Donovan A, Andrews NC, Clapham DE. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. October 31, 2008. Science (New York, N.Y.).

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  51. Cai X, Clapham DE. Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. October 30, 2008. PloS one.

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  52. Brauchi S, Krapivinsky G, Krapivinsky L, Clapham DE. TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. June 6, 2008. Proceedings of the National Academy of Sciences of the United States of America.

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  53. Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE. Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. May 7, 2008. PloS one.

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  54. Musset B, Cherny VV, Morgan D, Okamura Y, Ramsey IS, Clapham DE, DeCoursey TE. Detailed comparison of expressed and native voltage-gated proton channel currents. March 20, 2008. The Journal of physiology.

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  55. Rama S, Krapivinsky G, Clapham DE, Medina I. The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP. March 4, 2008. Molecular and cellular neurosciences.

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  56. Navarro B, Kirichok Y, Chung JJ, Clapham DE. Ion channels that control fertility in mammalian spermatozoa. January 1, 2008. The International journal of developmental biology.

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  57. Clapham DE. Calcium signaling. December 14, 2007. Cell.

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  58. Fujinami S, Sato T, Trimmer JS, Spiller BW, Clapham DE, Krulwich TA, Kawagishi I, Ito M. The voltage-gated Na+ channel NaVBP co-localizes with methyl-accepting chemotaxis protein at cell poles of alkaliphilic Bacillus pseudofirmus OF4. December 1, 2007. Microbiology (Reading, England).

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  59. Xu H, Delling M, Li L, Dong X, Clapham DE. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. November 7, 2007. Proceedings of the National Academy of Sciences of the United States of America.

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  60. Liu J, Xia J, Cho KH, Clapham DE, Ren D. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. May 3, 2007. The Journal of biological chemistry.

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  61. Navarro B, Kirichok Y, Clapham DE. KSper, a pH-sensitive K+ current that controls sperm membrane potential. April 25, 2007. Proceedings of the National Academy of Sciences of the United States of America.

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  62. Clapham DE. SnapShot: mammalian TRP channels. April 6, 2007. Cell.

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  63. Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE. All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. January 16, 2007. Proceedings of the National Academy of Sciences of the United States of America.

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  64. Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. November 22, 2006. Cell.

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  65. Krapivinsky G, Mochida S, Krapivinsky L, Cibulsky SM, Clapham DE. The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. November 9, 2006. Neuron.

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  66. Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. August 9, 2006. The Journal of biological chemistry.

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  67. Lambers TT, Mahieu F, Oancea E, Hoofd L, de Lange F, Mensenkamp AR, Voets T, Nilius B, Clapham DE, Hoenderop JG, Bindels RJ. Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. June 8, 2006. The EMBO journal.

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  68. Splawski I, Yoo DS, Stotz SC, Cherry A, Clapham DE, Keating MT. CACNA1H mutations in autism spectrum disorders. June 5, 2006. The Journal of biological chemistry.

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  69. Xu H, Delling M, Jun JC, Clapham DE. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. April 16, 2006. Nature neuroscience.

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  70. Ramsey IS, Moran MM, Chong JA, Clapham DE. A voltage-gated proton-selective channel lacking the pore domain. March 22, 2006. Nature.

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  71. Kirichok Y, Navarro B, Clapham DE. Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel. February 9, 2006. Nature.

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  72. Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. January 1, 2006. Annual review of physiology.

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  73. Oancea E, Wolfe JT, Clapham DE. Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow. December 15, 2005. Circulation research.

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  74. Clapham DE, Garbers DL. International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels. December 1, 2005. Pharmacological reviews.

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  75. Clapham DE, Julius D, Montell C, Schultz G. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. December 1, 2005. Pharmacological reviews.

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  76. Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. December 1, 2005. Pharmacological reviews.

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  77. Xu H, Blair NT, Clapham DE. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. September 28, 2005. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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  78. Desai BN, Clapham DE. TRP channels and mice deficient in TRP channels. August 3, 2005. Pflügers Archiv : European journal of physiology.

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  79. Reiser J, Polu KR, Möller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. May 27, 2005. Nature genetics.

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  80. Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE. TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP. April 1, 2005. Molecular and cellular biology.

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  81. Zhuang ZY, Xu H, Clapham DE, Ji RR. Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. September 22, 2004. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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  82. Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. August 19, 2004. Neuron.

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  83. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. Rapid vesicular translocation and insertion of TRP channels. July 18, 2004. Nature cell biology.

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  84. Ito M, Xu H, Guffanti AA, Wei Y, Zvi L, Clapham DE, Krulwich TA. The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus. July 8, 2004. Proceedings of the National Academy of Sciences of the United States of America.

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  85. Moran MM, Xu H, Clapham DE. TRP ion channels in the nervous system. June 1, 2004. Current opinion in neurobiology.

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  86. Xu H, Jin J, DeFelice LJ, Andrews NC, Clapham DE. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. March 16, 2004. PLoS biology.

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  87. Kirichok Y, Krapivinsky G, Clapham DE. The mitochondrial calcium uniporter is a highly selective ion channel. January 22, 2004. Nature.

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  88. Khositseth, A, Clapham DE, and Ackerman, M. Intracellular signaling and regulation of cardiac ion channels January 1, 2004. Cardiac Electrophysiology.

  89. 80. Ackerman, M, and Clapham DE. Excitability and Conduction January 1, 2004. The Molecular Basis of Heart Disease.

  90. Clapham DE. Symmetry, selectivity, and the 2003 Nobel Prize. December 12, 2003. Cell.

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  91. Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE. A superfamily of voltage-gated sodium channels in bacteria. December 9, 2003. The Journal of biological chemistry.

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  92. Clapham DE. TRP channels as cellular sensors. December 4, 2003. Nature.

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  93. Clapham DE, Montell C, Schultz G, Julius D. International Union of Pharmacology. XLIII. Compendium of voltage-gated ion channels: transient receptor potential channels. December 1, 2003. Pharmacological reviews.

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  94. Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. December 1, 2003. Pharmacological reviews.

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  95. Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF. CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. December 1, 2003. Proceedings of the National Academy of Sciences of the United States of America.

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  96. Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, Ben-Ari Y, Clapham DE, Medina I. The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. November 13, 2003. Neuron.

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  97. Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. August 1, 2003. Nature neuroscience.

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  98. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. Formation of novel TRPC channels by complex subunit interactions in embryonic brain. July 11, 2003. The Journal of biological chemistry.

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  99. Oancea E, Bezzerides VJ, Greka A, Clapham DE. Mechanism of persistent protein kinase D1 translocation and activation. April 1, 2003. Developmental cell.

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  100. Wei X, Henke VG, Strübing C, Brown EB, Clapham DE. Real-time imaging of nuclear permeation by EGFP in single intact cells. February 1, 2003. Biophysical journal.

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  101. Catterall, WA, Chandy, KG, Clapham, DE, Gutman, GA, Hofmann, F, Harmar, AJ, Abernethy, DR, and M. Spedding. International Union of Pharmacology: Approaches to the nomenclature of voltage-gated ion channels January 1, 2003. Pharmacological Reviews.

  102. Sandler VM, Wang S, Angelo K, Lo HG, Breakefield XO, Clapham DE. Modified herpes simplex virus delivery of enhanced GFP into the central nervous system. December 15, 2002. Journal of neuroscience methods.

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  103. Yue L, Navarro B, Ren D, Ramos A, Clapham DE. The cation selectivity filter of the bacterial sodium channel, NaChBac. December 1, 2002. The Journal of general physiology.

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  104. Clapham DE. Sorting out MIC, TRP, and CRAC ion channels. August 1, 2002. The Journal of general physiology.

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  105. Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE. TRPV3 is a calcium-permeable temperature-sensitive cation channel. June 23, 2002. Nature.

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  106. Runnels LW, Yue L, Clapham DE. The TRPM7 channel is inactivated by PIP(2) hydrolysis. May 1, 2002. Nature cell biology.

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  107. Clapham DE. Signal transduction. Hot and cold TRP ion channels. March 22, 2002. Science (New York, N.Y.).

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  108. Wickman K, Pu WT, Clapham DE. Structural characterization of the mouse Girk genes. February 6, 2002. Gene.

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  109. Montell C, Birnbaumer L, Flockerzi V, Bindels RJ, Bruford EA, Caterina MJ, Clapham DE, Harteneck C, Heller S, Julius D, Kojima I, Mori Y, Penner R, Prawitt D, Scharenberg AM, Schultz G, Shimizu N, Zhu MX. A unified nomenclature for the superfamily of TRP cation channels. February 1, 2002. Molecular cell.

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  110. Roberson, C, and Clapham, DE. . G protein-coupled receptor signaling through ion channels January 1, 2002. GPCRs in the CNS- The GPCR Superfamily.

  111. Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE. A prokaryotic voltage-gated sodium channel. December 14, 2001. Science (New York, N.Y.).

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  112. Quill TA, Ren D, Clapham DE, Garbers DL. A voltage-gated ion channel expressed specifically in spermatozoa. October 23, 2001. Proceedings of the National Academy of Sciences of the United States of America.

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  113. Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE. A sperm ion channel required for sperm motility and male fertility. October 11, 2001. Nature.

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  114. Clapham D, Michel T, Seidman C. In memorium. August 1, 2001. Journal of molecular and cellular cardiology.

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  115. Kovoor P, Wickman K, Maguire CT, Pu W, Gehrmann J, Berul CI, Clapham DE. Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. June 15, 2001. Journal of the American College of Cardiology.

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  116. Clapham DE, Runnels LW, Strübing C. The TRP ion channel family. June 1, 2001. Nature reviews. Neuroscience.

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  117. Lindroth AM, Saarikoski P, Flygh G, Clapham D, Grönroos R, Thelander M, Ronne H, von Arnold S. Two S-adenosylmethionine synthetase-encoding genes differentially expressed during adventitious root development in Pinus contorta. June 1, 2001. Plant molecular biology.

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  118. O'Connell PJ, Klyachko VA, Badminton MN, Thomson AW, Jackson MB, Clapham DE, Ahern GP. Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway. May 15, 2001. Journal of immunology (Baltimore, Md. : 1950).

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  119. Yue L, Peng JB, Hediger MA, Clapham DE. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. April 5, 2001. Nature.

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  120. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. March 1, 2001. Neuron.

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  121. Runnels LW, Yue L, Clapham DE. TRP-PLIK, a bifunctional protein with kinase and ion channel activities. January 18, 2001. Science (New York, N.Y.).

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  122. Corey S, Clapham DE. The Stoichiometry of Gbeta gamma binding to G-protein-regulated inwardly rectifying K+ channels (GIRKs). January 8, 2001. The Journal of biological chemistry.

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  123. Clapham D. How to lose your hippocampus by working on chloride channels. January 1, 2001. Neuron.

    Link to Abstract
  124. Clapham DE. . Intracellular calcium signaling January 1, 2001. Roger Eckert Memorial Lecture.

  125. Jelacic TM, Kennedy ME, Wickman K, Clapham DE. Functional and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3. November 17, 2000. The Journal of biological chemistry.

    Link to Abstract
  126. Medina I, Krapivinsky G, Arnold S, Kovoor P, Krapivinsky L, Clapham DE. A switch mechanism for G beta gamma activation of I(KACh). September 22, 2000. The Journal of biological chemistry.

    Link to Abstract
  127. Wickman K, Karschin C, Karschin A, Picciotto MR, Clapham DE. Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4. August 1, 2000. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  128. Franco-Obregón A, Wang HW, Clapham DE. Distinct ion channel classes are expressed on the outer nuclear envelope of T- and B-lymphocyte cell lines. July 1, 2000. Biophysical journal.

    Link to Abstract
  129. Pu WT, Wickman K, Clapham DE. ICln is essential for cellular and early embryonic viability. April 28, 2000. The Journal of biological chemistry.

    Link to Abstract
  130. Sabala I, Elfstrand M, Farbos I, Clapham D, von Arnold S. Tissue-specific expression of Pa18, a putative lipid transfer protein gene, during embryo development in Norway spruce (Picea abies). February 1, 2000. Plant molecular biology.

    Link to Abstract
  131. Clapham DE.. Remembering Eva Neer January 1, 2000. Cell.

  132. Clapham DE. More pieces of the K+ ion channel puzzle. September 1, 1999. Nature structural biology.

    Link to Abstract
  133. Wang H, Clapham DE. Conformational changes of the in situ nuclear pore complex. July 1, 1999. Biophysical journal.

    Link to Abstract
  134. Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE. pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. June 1, 1999. Molecular and cellular biology.

    Link to Abstract
  135. Clapham DE. Unlocking family secrets: K+ channel transmembrane domains. May 28, 1999. Cell.

    Link to Abstract
  136. Jelacic TM, Sims SM, Clapham DE. Functional expression and characterization of G-protein-gated inwardly rectifying K+ channels containing GIRK3. May 15, 1999. The Journal of membrane biology.

    Link to Abstract
  137. Arnold DB, Clapham DE. Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel. May 1, 1999. Neuron.

    Link to Abstract
  138. Wickman K, Krapivinsky G, Corey S, Kennedy M, Nemec J, Medina I, Clapham DE. Structure, G protein activation, and functional relevance of the cardiac G protein-gated K+ channel, IKACh. April 30, 1999. Annals of the New York Academy of Sciences.

    Link to Abstract
  139. Strübing C, Clapham DE. Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells. February 1, 1999. The Journal of general physiology.

    Link to Abstract
  140. Kennedy ME, Nemec J, Corey S, Wickman K, Clapham DE. GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. January 22, 1999. The Journal of biological chemistry.

    Link to Abstract
  141. Nemec J, Wickman K, Clapham DE. Gbetagamma binding increases the open time of IKACh: kinetic evidence for multiple Gbetagamma binding sites. January 1, 1999. Biophysical journal.

    Link to Abstract
  142. Ackerman, M, and Clapham DE.. G proteins and ion channels January 1, 1999. Cardiac Electrophysiology.

  143. Navarro, B, Corey, S, Kennedy, M, and Clapham DE. G-protein-gated potassium channels: Implications for the weaver mouse January 1, 1999. Potassium Ion Channels: Molecular Structure, Function, and Diseases.

  144. Franco-Obregón A, Clapham DE. Touch channels sense blood pressure. December 1, 1998. Neuron.

    Link to Abstract
  145. Corey S, Clapham DE. Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. October 16, 1998. The Journal of biological chemistry.

    Link to Abstract
  146. Krapivinsky G, Kennedy ME, Nemec J, Medina I, Krapivinsky L, Clapham DE. Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation. July 3, 1998. The Journal of biological chemistry.

    Link to Abstract
  147. Clapham DE. Not so funny anymore: pacing channels are cloned. July 1, 1998. Neuron.

    Link to Abstract
  148. Schiller J, Schiller Y, Clapham DE. NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation. June 1, 1998. Nature neuroscience.

    Link to Abstract
  149. Clapham DE. The list of potential volume-sensitive chloride currents continues to swell (and shrink). May 1, 1998. The Journal of general physiology.

    Link to Abstract
  150. Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE. pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. May 1, 1998. The Journal of biological chemistry.

    Link to Abstract
  151. Krapivinsky G, Medina I, Eng L, Krapivinsky L, Yang Y, Clapham DE. A novel inward rectifier K+ channel with unique pore properties. May 1, 1998. Neuron.

    Link to Abstract
  152. Clapham DE. At last, the structure of an ion-selective channel. May 1, 1998. Nature structural biology.

    Link to Abstract
  153. Lorenz E, Alekseev AE, Krapivinsky GB, Carrasco AJ, Clapham DE, Terzic A. Evidence for direct physical association between a K+ channel (Kir6.2) and an ATP-binding cassette protein (SUR1) which affects cellular distribution and kinetic behavior of an ATP-sensitive K+ channel. March 1, 1998. Molecular and cellular biology.

    Link to Abstract
  154. Corey S, Krapivinsky G, Krapivinsky L, Clapham DE. Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channel, IKACh. February 27, 1998. The Journal of biological chemistry.

    Link to Abstract
  155. Lee MA, Dunn RC, Clapham DE, Stehno-Bittel L. Calcium regulation of nuclear pore permeability. February 1, 1998. Cell calcium.

    Link to Abstract
  156. Wickman K, Nemec J, Gendler SJ, Clapham DE. Abnormal heart rate regulation in GIRK4 knockout mice. January 1, 1998. Neuron.

    Link to Abstract
  157. Clapham DE. Some like it hot: spicing up ion channels. October 23, 1997. Nature.

    Link to Abstract
  158. Perez-Terzic C, Jaconi M, Clapham DE. Nuclear calcium and the regulation of the nuclear pore complex. September 1, 1997. BioEssays : news and reviews in molecular, cellular and developmental biology.

    Link to Abstract
  159. Jaconi M, Pyle J, Bortolon R, Ou J, Clapham D. Calcium release and influx colocalize to the endoplasmic reticulum. August 1, 1997. Current biology : CB.

    Link to Abstract
  160. Ackerman MJ, Clapham DE. Ion channels--basic science and clinical disease. May 29, 1997. The New England journal of medicine.

    Link to Abstract
  161. Perez-Terzic C, Stehno-Bittel L, Clapham DE. Nucleoplasmic and cytoplasmic differences in the fluorescence properties of the calcium indicator Fluo-3. April 1, 1997. Cell calcium.

    Link to Abstract
  162. Wickman K, Seldin MF, James MR, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Icln gene. March 15, 1997. Genomics.

    Link to Abstract
  163. Wickman K, Seldin MF, Gendler SJ, Clapham DE. Partial structure, chromosome localization, and expression of the mouse Girk4 gene. March 15, 1997. Genomics.

    Link to Abstract
  164. Clapham DE, Neer EJ. G protein beta gamma subunits. January 1, 1997. Annual review of pharmacology and toxicology.

    Link to Abstract
  165. Clapham DE. The molecular control of cardiac ion channels. January 1, 1997. Heart and vessels.

    Link to Abstract
  166. Perez-Terzic C, Pyle J, Jaconi M, Stehno-Bittel L, Clapham DE. Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores. September 27, 1996. Science (New York, N.Y.).

    Link to Abstract
  167. Clapham DE. Intracellular signalling: more jobs for G beta gamma. July 1, 1996. Current biology : CB.

    Link to Abstract
  168. Navarro B, Kennedy ME, Velimirovíc B, Bhat D, Peterson AS, Clapham DE. Nonselective and G betagamma-insensitive weaver K+ channels. June 28, 1996. Science (New York, N.Y.).

    Link to Abstract
  169. Saarikoski P, Clapham D, von Arnold S. A wound-inducible gene from Salix viminalis coding for a trypsin inhibitor. June 1, 1996. Plant molecular biology.

    Link to Abstract
  170. Aleksandrov A, Velimirovic B, Clapham DE. Inward rectification of the IRK1 K+ channel reconstituted in lipid bilayers. June 1, 1996. Biophysical journal.

    Link to Abstract
  171. Clapham DE. TRP is cracked but is CRAC TRP? June 1, 1996. Neuron.

    Link to Abstract
  172. Hedin KE, Lim NF, Clapham DE. Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes. February 1, 1996. Neuron.

    Link to Abstract
  173. Clapham DE. The G-protein nanomachine. January 25, 1996. Nature.

    Link to Abstract
  174. Velimirovic BM, Gordon EA, Lim NF, Navarro B, Clapham DE. The K+ channel inward rectifier subunits form a channel similar to neuronal G protein-gated K+ channel. January 22, 1996. FEBS letters.

    Link to Abstract
  175. Kennedy ME, Nemec J, Clapham DE. Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+ channel subunits. January 1, 1996. Neuropharmacology.

    Link to Abstract
  176. Stehno-Bittel L, Perez-Terzic C, Luckhoff A, Clapham DE. Nuclear ion channels and regulation of the nuclear pore. January 1, 1996. Society of General Physiologists series.

    Link to Abstract
  177. Perez-Terzic CM, Chini EN, Shen SS, Dousa TP, Clapham DE. Ca2+ release triggered by nicotinate adenine dinucleotide phosphate in intact sea urchin eggs. December 15, 1995. The Biochemical journal.

    Link to Abstract
  178. Stehno-Bittel L, Krapivinsky G, Krapivinsky L, Perez-Terzic C, Clapham DE. The G protein beta gamma subunit transduces the muscarinic receptor signal for Ca2+ release in Xenopus oocytes. December 15, 1995. The Journal of biological chemistry.

    Link to Abstract
  179. Stehno-Bittel L, Perez-Terzic C, Clapham DE. Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+ store. December 15, 1995. Science (New York, N.Y.).

    Link to Abstract
  180. Krapivinsky G, Krapivinsky L, Wickman K, Clapham DE. G beta gamma binds directly to the G protein-gated K+ channel, IKACh. December 8, 1995. The Journal of biological chemistry.

    Link to Abstract
  181. Krapivinsky G, Krapivinsky L, Velimirovic B, Wickman K, Navarro B, Clapham DE. The cardiac inward rectifier K+ channel subunit, CIR, does not comprise the ATP-sensitive K+ channel, IKATP. December 1, 1995. The Journal of biological chemistry.

    Link to Abstract
  182. Wickman K, Clapham DE. Ion channel regulation by G proteins. October 1, 1995. Physiological reviews.

    Link to Abstract
  183. Clapham DE. Intracellular calcium. Replenishing the stores. June 22, 1995. Nature.

    Link to Abstract
  184. Wickman KD, Clapham DE. G-protein regulation of ion channels. June 1, 1995. Current opinion in neurobiology.

    Link to Abstract
  185. Krapivinsky G, Gordon EA, Wickman K, Velimirovic B, Krapivinsky L, Clapham DE. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. March 9, 1995. Nature.

    Link to Abstract
  186. Hedin KE, Appleby MW, Clapham DE. Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes. February 1, 1995. Immunology.

    Link to Abstract
  187. Clapham DE. Calcium signaling. January 27, 1995. Cell.

    Link to Abstract
  188. Stehno-Bittel L, Lückhoff A, Clapham DE. Calcium release from the nucleus by InsP3 receptor channels. January 1, 1995. Neuron.

    Link to Abstract
  189. Clapham DE, Sneyd J. Intracellular calcium waves. January 1, 1995. Advances in second messenger and phosphoprotein research.

    Link to Abstract
  190. Clapham DE. Signal transduction. Why testicles are cool. September 8, 1994. Nature.

    Link to Abstract
  191. Lückhoff A, Clapham DE. Calcium channels activated by depletion of internal calcium stores in A431 cells. July 1, 1994. Biophysical journal.

    Link to Abstract
  192. Wickman KD, Iñiguez-Lluhl JA, Davenport PA, Taussig R, Krapivinsky GB, Linder ME, Gilman AG, Clapham DE. Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. March 17, 1994. Nature.

    Link to Abstract
  193. Krapivinsky GB, Ackerman MJ, Gordon EA, Krapivinsky LD, Clapham DE. Molecular characterization of a swelling-induced chloride conductance regulatory protein, pICln. February 11, 1994. Cell.

    Link to Abstract
  194. Ackerman MJ, Wickman KD, Clapham DE. Hypotonicity activates a native chloride current in Xenopus oocytes. February 1, 1994. The Journal of general physiology.

    Link to Abstract
  195. Girard S, Clapham DE. Simultaneous near ultraviolet and visible excitation confocal microscopy of calcium transients in Xenopus oocytes. January 1, 1994. Methods in cell biology.

    Link to Abstract
  196. Clapham DE. Direct G protein activation of ion channels? January 1, 1994. Annual review of neuroscience.

    Link to Abstract
  197. Stehno-Bittel L, Amundson J, Clapham D. G-protein-mediated pathways assayed by electrophysiology and confocal microscopy. January 1, 1994. Methods in enzymology.

    Link to Abstract
  198. Ackerman MJ, Krapivinsky GB, Gordon E, Krapivinsky L, Clapham DC. Characterization of a native swelling-induced chloride current, ICl.swell, and its regulatory protein, pICln, in Xenopus oocytes. January 1, 1994. The Japanese journal of physiology.

    Link to Abstract
  199. Clapham DE. Mutations in G protein-linked receptors: novel insights on disease. December 31, 1993. Cell.

    Link to Abstract
  200. Chris Bliton, James Lechleiter, and David Clapham. Confocal imaging system for visible and ultraviolet light November 9, 1993. Confocal imaging system for visible and ultraviolet light.

  201. Atri A, Amundson J, Clapham D, Sneyd J. A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte. October 1, 1993. Biophysical journal.

    Link to Abstract
  202. Clapham DE, Neer EJ. New roles for G-protein beta gamma-dimers in transmembrane signalling. September 30, 1993. Nature.

    Link to Abstract
  203. Hedin KE, Duerson K, Clapham DE. Specificity of receptor-G protein interactions: searching for the structure behind the signal. September 1, 1993. Cellular signalling.

    Link to Abstract
  204. Clapham DE. Cellular calcium. A mysterious new influx factor? August 26, 1993. Nature.

    Link to Abstract
  205. Clapham DE. Reply. July 1, 1993. Trends in cardiovascular medicine.

    Link to Abstract
  206. Duerson K, Carroll R, Clapham D. Alpha-helical distorting substitution disrupt coupling between m3 muscarinic receptor and G proteins. June 7, 1993. FEBS letters.

    Link to Abstract
  207. Amundson J, Clapham D. Calcium waves. June 1, 1993. Current opinion in neurobiology.

    Link to Abstract
  208. Girard S, Clapham D. Acceleration of intracellular calcium waves in Xenopus oocytes by calcium influx. April 9, 1993. Science (New York, N.Y.).

    Link to Abstract
  209. Sneyd J, Girard S, Clapham D. Calcium wave propagation by calcium-induced calcium release: an unusual excitable system. March 1, 1993. Bulletin of mathematical biology.

    Link to Abstract
  210. Ackerman MJ, Clapham DE. Cardiac chloride channels. January 1, 1993. Trends in cardiovascular medicine.

    Link to Abstract
  211. Clapham DE, Lechleiter JD, Girard S. Intracellular waves observed by confocal microscopy from Xenopus oocytes. January 1, 1993. Advances in second messenger and phosphoprotein research.

    Link to Abstract
  212. Lechleiter JD, Clapham DE. Molecular mechanisms of intracellular calcium excitability in X. laevis oocytes. April 17, 1992. Cell.

    Link to Abstract
  213. Paulmichl M, Li Y, Wickman K, Ackerman M, Peralta E, Clapham D. New mammalian chloride channel identified by expression cloning. March 19, 1992. Nature.

    Link to Abstract
  214. Girard S, Lückhoff A, Lechleiter J, Sneyd J, Clapham D. Two-dimensional model of calcium waves reproduces the patterns observed in Xenopus oocytes. February 1, 1992. Biophysical journal.

    Link to Abstract
  215. Lückhoff A, Clapham DE. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca(2+)-permeable channel. January 23, 1992. Nature.

    Link to Abstract
  216. Lechleiter JD, Clapham DE. Spiral waves and intracellular calcium signalling. January 1, 1992. Journal of physiology, Paris.

    Link to Abstract
  217. Neer EJ, Clapham DE. Signal transduction through G proteins in the cardiac myocyte. January 1, 1992. Trends in cardiovascular medicine.

    Link to Abstract
  218. Wallert MA, Ackerman MJ, Kim D, Clapham DE. Two novel cardiac atrial K+ channels, IK.AA and IK.PC. November 1, 1991. The Journal of general physiology.

    Link to Abstract
  219. Paulmichl M, Nasmith P, Hellmiss R, Reed K, Boyle WA, Nerbonne JM, Peralta EG, Clapham DE. Cloning and expression of a rat cardiac delayed rectifier potassium channel. September 1, 1991. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  220. Tabares L, Mazzanti M, Clapham DE. Chloride channels in the nuclear membrane. July 1, 1991. The Journal of membrane biology.

    Link to Abstract
  221. Lechleiter J, Girard S, Clapham D, Peralta E. Subcellular patterns of calcium release determined by G protein-specific residues of muscarinic receptors. April 11, 1991. Nature.

    Link to Abstract
  222. Lechleiter J, Girard S, Peralta E, Clapham D. Spiral calcium wave propagation and annihilation in Xenopus laevis oocytes. April 5, 1991. Science (New York, N.Y.).

    Link to Abstract
  223. Lechleiter J, Hellmiss R, Duerson K, Ennulat D, David N, Clapham D, Peralta E. Distinct sequence elements control the specificity of G protein activation by muscarinic acetylcholine receptor subtypes. December 1, 1990. The EMBO journal.

    Link to Abstract
  224. Lewis DL, Lechleiter JD, Kim D, Nanavati C, Clapham DE. Intracellular regulation of ion channels in cell membranes. August 1, 1990. Mayo Clinic proceedings. Mayo Clinic.

    Link to Abstract
  225. Clapham DE. Arachidonic acid and its metabolites in the regulation of G-protein gated K+ channels in atrial myocytes. March 1, 1990. Biochemical pharmacology.

    Link to Abstract
  226. Nanavati C, Clapham DE, Ito H, Kurachi Y. A comparison of the roles of purified G protein subunits in the activation of the cardiac muscarinic K+ channel. January 1, 1990. Society of General Physiologists series.

    Link to Abstract
  227. Lechleiter J, Peralta E, Clapham D. Diverse functions of muscarinic acetylcholine receptor subtypes. December 1, 1989. Trends in pharmacological sciences.

    Link to Abstract
  228. Lewis DL, Clapham DE. Somatostatin activates an inwardly rectifying K+ channel in neonatal rat atrial cells. August 1, 1989. Pflügers Archiv : European journal of physiology.

    Link to Abstract
  229. Kim D, Clapham DE. Potassium channels in cardiac cells activated by arachidonic acid and phospholipids. June 9, 1989. Science (New York, N.Y.).

    Link to Abstract
  230. Kim D, Lewis DL, Graziadei L, Neer EJ, Bar-Sagi D, Clapham DE. G-protein beta gamma-subunits activate the cardiac muscarinic K+-channel via phospholipase A2. February 9, 1989. Nature.

    Link to Abstract
  231. Clapham DE, Kim D. G protein activation mechanisms of the cardiac K+ channel, iK.ACh. January 1, 1989. Society of General Physiologists series.

    Link to Abstract
  232. Logothetis DE, Kim DH, Northup JK, Neer EJ, Clapham DE. Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. August 1, 1988. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  233. Clapham D, Neer E. Activation of atrial muscarinic-gated K+ channels by beta gamma-subunits of G proteins. June 1, 1988. The American journal of physiology.

    Link to Abstract
  234. Davies PF, Olesen SP, Clapham DE, Morrel EM, Schoen FJ. Endothelial communication. State of the art lecture. June 1, 1988. Hypertension.

    Link to Abstract
  235. Olesen SP, Davies PF, Clapham DE. Muscarinic-activated K+ current in bovine aortic endothelial cells. June 1, 1988. Circulation research.

    Link to Abstract
  236. Neer EJ, Clapham DE. Roles of G protein subunits in transmembrane signalling. May 12, 1988. Nature.

    Link to Abstract
  237. Fish RD, Sperti G, Colucci WS, Clapham DE. Phorbol ester increases the dihydropyridine-sensitive calcium conductance in a vascular smooth muscle cell line. May 1, 1988. Circulation research.

    Link to Abstract
  238. Olesen SP, Clapham DE, Davies PF. Haemodynamic shear stress activates a K+ current in vascular endothelial cells. January 14, 1988. Nature.

    Link to Abstract
  239. Clapham DE, Logothetis DE. Delayed rectifier K+ current in embryonic chick heart ventricle. January 1, 1988. The American journal of physiology.

    Link to Abstract
  240. Logothetis DE, Kurachi Y, Galper J, Neer EJ, Clapham DE. The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart. January 1, 1987. Nature.

    Link to Abstract
  241. Bormann J, Clapham DE. gamma-Aminobutyric acid receptor channels in adrenal chromaffin cells: a patch-clamp study. April 1, 1985. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  242. Clapham DE, Neher E. Trifluoperazine reduces inward ionic currents and secretion by separate mechanisms in bovine chromaffin cells. August 1, 1984. The Journal of physiology.

    Link to Abstract
  243. Ypey DL, Clapham DE. Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages. May 1, 1984. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  244. Clapham DE, Neher E. Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. February 1, 1984. The Journal of physiology.

    Link to Abstract
  245. Clapham DE, Defelice LJ. Voltage-activated k channels in embryonic chick heart. January 1, 1984. Biophysical journal.

    Link to Abstract
  246. Clapham DE, DeFelice LJ. Small signal impedance of heart cell membranes. January 1, 1982. The Journal of membrane biology.

    Link to Abstract
  247. Clapham DE, Shrier A, DeHaan RL. Junctional resistance and action potential delay between embryonic heart cell aggregates. June 1, 1980. The Journal of general physiology.

    Link to Abstract
  248. Ypey DL, Clapham DE, DeHaan RL. Development of electrical coupling and action potential synchrony between paired aggregates of embryonic heart cells. December 12, 1979. The Journal of membrane biology.

    Link to Abstract
  249. Clapham DE, De Felice LJ. The theoretical small signal impedance of the frog node, Rana pipiens. November 5, 1976. Pflügers Archiv : European journal of physiology.

    Link to Abstract

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