David D Ginty, Ph.D.

Edward R. and Anne G. Lefler Professor of Neurobiology
  • Ginty Lab - HHMI
  • 617-432-2175

Our laboratory uses mouse molecular genetics, in vitro signaling approaches, circuit mapping, and electrophysiological analyses to gain understanding of the development, organization, and function of neural circuits that underlie the sense of touch. Mouse molecular genetic approaches are used to identify, visualize, and functionally manipulate each of the physiologically defined classes of low-threshold mechanosensory neurons (LTMRs), the primary cutaneous sensory neurons that mediate the sense of touch. Our current goals are to discover: 1) the unique functions and properties of LTMR subtypes; 2) the organization of synaptic connections between LTMR subtypes, spinal cord dorsal horn interneurons and projection neurons, and dorsal column nuclei neurons; 3) the neural circuits that underlie the perception of touch, and; 4) molecular and developmental mechanisms by which primary somatosensory neurons and touch circuit organization are established.

  1. Mandai K, Reimert DV, Ginty DD. Linx mediates interaxonal interactions and formation of the internal capsule. June 12, 2014. Neuron.

    Link to Abstract
  2. Li L, Ginty DD. The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles. February 25, 2014. eLife.

    Link to Abstract
  3. Engelhard C, Sarsfield S, Merte J, Wang Q, Li P, Beppu H, Kolodkin AL, Sucov HM, Ginty DD. MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. September 17, 2013. eLife.

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  4. Abraira VE, Ginty DD. The sensory neurons of touch. August 21, 2013. Neuron.

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  5. Harrington AW, Ginty DD. Long-distance retrograde neurotrophic factor signalling in neurons. March 1, 2013. Nature reviews. Neuroscience.

    Link to Abstract
  6. Liu Y, Rutlin M, Huang S, Barrick CA, Wang F, Jones KR, Tessarollo L, Ginty DD. Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland. December 7, 2012. Science (New York, N.Y.).

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  7. Wright KM, Lyon KA, Leung H, Leahy DJ, Ma L, Ginty DD. Dystroglycan organizes axon guidance cue localization and axonal pathfinding. December 6, 2012. Neuron.

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  8. de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH. Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. June 10, 2012. Nature neuroscience.

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  9. Li L, Rutlin M, Abraira VE, Cassidy C, Kus L, Gong S, Jankowski MP, Luo W, Heintz N, Koerber HR, Woodbury CJ, Ginty DD. The functional organization of cutaneous low-threshold mechanosensory neurons. December 23, 2011. Cell.

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  10. Harrington AW, St Hillaire C, Zweifel LS, Glebova NO, Philippidou P, Halegoua S, Ginty DD. Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival. August 5, 2011. Cell.

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  11. Guo T, Mandai K, Condie BG, Wickramasinghe SR, Capecchi MR, Ginty DD. An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. December 12, 2010. Nature neuroscience.

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  12. Sharma N, Deppmann CD, Harrington AW, St Hillaire C, Chen ZY, Lee FS, Ginty DD. Long-distance control of synapse assembly by target-derived NGF. August 12, 2010. Neuron.

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  13. Smith-Hicks C, Xiao B, Deng R, Ji Y, Zhao X, Shepherd JD, Posern G, Kuhl D, Huganir RL, Ginty DD, Worley PF, Linden DJ. SRF binding to SRE 6.9 in the Arc promoter is essential for LTD in cultured Purkinje cells. August 8, 2010. Nature neuroscience.

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  14. Merte J, Wang Q, Vander Kooi CW, Sarsfield S, Leahy DJ, Kolodkin AL, Ginty DD. A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal. April 21, 2010. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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  15. Luo W, Enomoto H, Rice FL, Milbrandt J, Ginty DD. Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling. December 24, 2009. Neuron.

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  16. Tran TS, Rubio ME, Clem RL, Johnson D, Case L, Tessier-Lavigne M, Huganir RL, Ginty DD, Kolodkin AL. Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. December 13, 2009. Nature.

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  17. Merte J, Jensen D, Wright K, Sarsfield S, Wang Y, Schekman R, Ginty DD. Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. December 6, 2009. Nature cell biology.

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  18. Kolk SM, Gunput RA, Tran TS, van den Heuvel DM, Prasad AA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ. Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. October 7, 2009. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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  19. Mandai K, Guo T, St Hillaire C, Meabon JS, Kanning KC, Bothwell M, Ginty DD. LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. September 10, 2009. Neuron.

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  20. Newbern J, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE. Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. October 24, 2008. Proceedings of the National Academy of Sciences of the United States of America.

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  21. Johnson AW, Chen X, Crombag HS, Zhang C, Smith DR, Shokat KM, Gallagher M, Holland PC, Ginty DD. The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value. July 26, 2008. The European journal of neuroscience.

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  22. Wickramasinghe SR, Alvania RS, Ramanan N, Wood JN, Mandai K, Ginty DD. Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. May 22, 2008. Neuron.

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  23. Makita T, Sucov HM, Gariepy CE, Yanagisawa M, Ginty DD. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. April 10, 2008. Nature.

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  24. Deppmann CD, Mihalas S, Sharma N, Lonze BE, Niebur E, Ginty DD. A model for neuronal competition during development. March 6, 2008. Science (New York, N.Y.).

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  25. Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty DD. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. June 7, 2007. Neuron.

    Link to Abstract
  26. Deppmann CD, Ginty DD. Retrograde control of neural circuit formation. December 29, 2006. Cell.

    Link to Abstract
  27. Alvania RS, Chen X, Ginty DD. Calcium signals control Wnt-dependent dendrite growth. June 15, 2006. Neuron.

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  28. Riccio A, Alvania RS, Lonze BE, Ramanan N, Kim T, Huang Y, Dawson TM, Snyder SH, Ginty DD. A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. January 20, 2006. Molecular cell.

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  29. Huber AB, Kania A, Tran TS, Gu C, De Marco Garcia N, Lieberam I, Johnson D, Jessell TM, Ginty DD, Kolodkin AL. Distinct roles for secreted semaphorin signaling in spinal motor axon guidance. December 22, 2005. Neuron.

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  30. Lee J, Kim CH, Simon DK, Aminova LR, Andreyev AY, Kushnareva YE, Murphy AN, Lonze BE, Kim KS, Ginty DD, Ferrante RJ, Ryu H, Ratan RR. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. October 5, 2005. The Journal of biological chemistry.

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  31. Zweifel LS, Kuruvilla R, Ginty DD. Functions and mechanisms of retrograde neurotrophin signalling. August 1, 2005. Nature reviews. Neuroscience.

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  32. Valdez G, Akmentin W, Philippidou P, Kuruvilla R, Ginty DD, Halegoua S. Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors. May 25, 2005. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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  33. Ramanan N, Shen Y, Sarsfield S, Lemberger T, Schütz G, Linden DJ, Ginty DD. SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. May 8, 2005. Nature neuroscience.

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  34. Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD. A chemical-genetic approach to studying neurotrophin signaling. April 7, 2005. Neuron.

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  35. Sahay A, Kim CH, Sepkuty JP, Cho E, Huganir RL, Ginty DD, Kolodkin AL. Secreted semaphorins modulate synaptic transmission in the adult hippocampus. April 6, 2005. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  36. Glebova NO, Ginty DD. Growth and survival signals controlling sympathetic nervous system development. January 1, 2005. Annual review of neuroscience.

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  37. Miano JM, Ramanan N, Georger MA, de Mesy Bentley KL, Emerson RL, Balza RO, Xiao Q, Weiler H, Ginty DD, Misra RP. Restricted inactivation of serum response factor to the cardiovascular system. November 29, 2004. Proceedings of the National Academy of Sciences of the United States of America.

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  38. Chen AE, Ginty DD, Fan CM. Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. November 28, 2004. Nature.

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  39. Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. November 18, 2004. Science (New York, N.Y.).

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  40. Schwarz Q, Gu C, Fujisawa H, Sabelko K, Gertsenstein M, Nagy A, Taniguchi M, Kolodkin AL, Ginty DD, Shima DT, Ruhrberg C. Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. November 15, 2004. Genes & development.

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  41. Cloutier JF, Sahay A, Chang EC, Tessier-Lavigne M, Dulac C, Kolodkin AL, Ginty DD. Differential requirements for semaphorin 3F and Slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections. October 13, 2004. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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  42. Kuruvilla R, Zweifel LS, Glebova NO, Lonze BE, Valdez G, Ye H, Ginty DD. A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. July 23, 2004. Cell.

    Link to Abstract
  43. Glebova NO, Ginty DD. Heterogeneous requirement of NGF for sympathetic target innervation in vivo. January 21, 2004. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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  44. Sahay A, Molliver ME, Ginty DD, Kolodkin AL. Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events. July 30, 2003. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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  45. Ye H, Kuruvilla R, Zweifel LS, Ginty DD. Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons. July 3, 2003. Neuron.

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  46. Gu C, Rodriguez ER, Reimert DV, Shu T, Fritzsch B, Richards LJ, Kolodkin AL, Ginty DD. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. July 1, 2003. Developmental cell.

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  47. Huber AB, Kolodkin AL, Ginty DD, Cloutier JF. Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. March 28, 2003. Annual review of neuroscience.

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  48. Lonze BE, Ginty DD. Function and regulation of CREB family transcription factors in the nervous system. August 15, 2002. Neuron.

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  49. Ginty DD, Segal RA. Retrograde neurotrophin signaling: Trk-ing along the axon. June 1, 2002. Current opinion in neurobiology.

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  50. Dawson TM, Ginty DD. CREB family transcription factors inhibit neuronal suicide. May 1, 2002. Nature medicine.

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  51. Riccio A, Ginty DD. What a privilege to reside at the synapse: NMDA receptor signaling to CREB. May 1, 2002. Nature neuroscience.

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  52. Lonze BE, Riccio A, Cohen S, Ginty DD. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. April 25, 2002. Neuron.

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  53. Cloutier JF, Giger RJ, Koentges G, Dulac C, Kolodkin AL, Ginty DD. Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence, of primary accessory olfactory neurons. March 14, 2002. Neuron.

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  54. Gu C, Limberg BJ, Whitaker GB, Perman B, Leahy DJ, Rosenbaum JS, Ginty DD, Kolodkin AL. Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. March 8, 2002. The Journal of biological chemistry.

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  55. Qian X, Ginty DD. SH2-B and APS are multimeric adapters that augment TrkA signaling. March 1, 2001. Molecular and cellular biology.

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  56. Kuruvilla R, Ye H, Ginty DD. Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons. September 1, 2000. Neuron.

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  57. Sasaki M, Gonzalez-Zulueta M, Huang H, Herring WJ, Ahn S, Ginty DD, Dawson VL, Dawson TM. Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism. July 18, 2000. Proceedings of the National Academy of Sciences of the United States of America.

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  58. Giger RJ, Cloutier JF, Sahay A, Prinjha RK, Levengood DV, Moore SE, Pickering S, Simmons D, Rastan S, Walsh FS, Kolodkin AL, Ginty DD, Geppert M. Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins. January 1, 2000. Neuron.

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  59. Riccio A, Ahn S, Davenport CM, Blendy JA, Ginty DD. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. December 17, 1999. Science (New York, N.Y.).

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  60. Tsui-Pierchala BA, Ginty DD. Characterization of an NGF-P-TrkA retrograde-signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons. October 1, 1999. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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  61. Ahn S, Ginty DD, Linden DJ. A late phase of cerebellar long-term depression requires activation of CaMKIV and CREB. July 1, 1999. Neuron.

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  62. Polleux F, Giger RJ, Ginty DD, Kolodkin AL, Ghosh A. Patterning of cortical efferent projections by semaphorin-neuropilin interactions. December 4, 1998. Science (New York, N.Y.).

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  63. Naruse S, Thinakaran G, Luo JJ, Kusiak JW, Tomita T, Iwatsubo T, Qian X, Ginty DD, Price DL, Borchelt DR, Wong PC, Sisodia SS. Effects of PS1 deficiency on membrane protein trafficking in neurons. November 1, 1998. Neuron.

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  64. Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL. Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity. November 1, 1998. Neuron.

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  65. Qian X, Riccio A, Zhang Y, Ginty DD. Identification and characterization of novel substrates of Trk receptors in developing neurons. November 1, 1998. Neuron.

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  66. Ahn S, Olive M, Aggarwal S, Krylov D, Ginty DD, Vinson C. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos. February 1, 1998. Molecular and cellular biology.

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  67. Kolodkin AL, Ginty DD. Steering clear of semaphorins: neuropilins sound the retreat. December 1, 1997. Neuron.

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  68. Riccio A, Pierchala BA, Ciarallo CL, Ginty DD. An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons. August 22, 1997. Science (New York, N.Y.).

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  69. Xing J, Ginty DD, Greenberg ME. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. August 16, 1996. Science (New York, N.Y.).

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  70. Miranti CK, Ginty DD, Huang G, Chatila T, Greenberg ME. Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase. July 1, 1995. Molecular and cellular biology.

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  71. Bonni A, Ginty DD, Dudek H, Greenberg ME. Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals. April 1, 1995. Molecular and cellular neurosciences.

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  72. Thompson MA, Ginty DD, Bonni A, Greenberg ME. L-type voltage-sensitive Ca2+ channel activation regulates c-fos transcription at multiple levels. March 3, 1995. The Journal of biological chemistry.

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  73. Rosen LB, Ginty DD, Weber MJ, Greenberg ME. Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. June 1, 1994. Neuron.

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  74. Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. October 1, 1993. Molecular and cellular biology.

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  75. Bading H, Ginty DD, Greenberg ME. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. April 9, 1993. Science (New York, N.Y.).

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  76. Ginty DD, Bading H, Greenberg ME. Trans-synaptic regulation of gene expression. June 1, 1992. Current opinion in neurobiology.

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  77. Ginty DD, Fanger GR, Wagner JA, Maue RA. The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells. March 1, 1992. The Journal of cell biology.

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  78. Ginty DD, Glowacka D, Bader DS, Hidaka H, Wagner JA. Induction of immediate early genes by Ca2+ influx requires cAMP-dependent protein kinase in PC12 cells. September 15, 1991. The Journal of biological chemistry.

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  79. Ginty DD, Glowacka D, DeFranco C, Wagner JA. Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent protein kinase activities. August 15, 1991. The Journal of biological chemistry.

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  80. Scheibe RJ, Ginty DD, Wagner JA. Retinoic acid stimulates the differentiation of PC12 cells that are deficient in cAMP-dependent protein kinase. June 1, 1991. The Journal of cell biology.

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  81. Ginty DD, Marlowe M, Pekala PH, Seidel ER. Multiple pathways for the regulation of ornithine decarboxylase in intestinal epithelial cells. March 1, 1990. The American journal of physiology.

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  82. Ginty DD, Osborne DL, Seidel ER. Putrescine stimulates DNA synthesis in intestinal epithelial cells. July 1, 1989. The American journal of physiology.

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  83. Ginty DD, Seidel ER. Polyamine-dependent growth and calmodulin-regulated induction of ornithine decarboxylase. February 1, 1989. The American journal of physiology.

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  84. Hargittai PT, Ginty DD, Lieberman EM. A pyrene fluorescence technique and microchamber for measurement of oxygen consumption of single isolated axons. June 1, 1987. Analytical biochemistry.

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Harvard Medical School
Department of Neurobiology
210 Longwood Avenue, Armenise 437
Boston, MA 02115