David D Ginty

  • Ginty Lab - HHMI
  • 617-432-2175

Our laboratory uses mouse molecular genetics, in vitro signaling approaches, circuit mapping, and electrophysiological analyses to gain understanding of the development, organization, and function of neural circuits that underlie the sense of touch. Mouse molecular genetic approaches are used to identify, visualize, and functionally manipulate each of the physiologically defined classes of low-threshold mechanosensory neurons (LTMRs), the primary cutaneous sensory neurons that mediate the sense of touch. Our current goals are to discover: 1) the unique functions and properties of LTMR subtypes; 2) the organization of synaptic connections between LTMR subtypes, spinal cord dorsal horn interneurons and projection neurons, and dorsal column nuclei neurons; 3) the neural circuits that underlie the perception of touch, and; 4) molecular and developmental mechanisms by which primary somatosensory neurons and touch circuit organization are established.

Harvard Medical School
Department of Neurobiology
210 Longwood Avenue, Armenise 437
Boston, MA 02115