Michael Greenberg, Ph.D.

Nathan Marsh Pusey Professor of Neurobiology
  • 617/432-2510

Our interactions with the outside world trigger changes at neuronal synapses that are critical for proper brain development and higher cognitive function. Research in the Greenberg laboratory has focused on the identification of a genetic program that is activated by neuronal activity, the mechanisms of signal transduction that carry the neuronal activity-dependent signal from the membrane to the nucleus, and the identification of regulators of this experience-dependent process that affect synapse development and plasticity. We are particularly interested in those activity-dependent processes whose dysfunction can lead to the development of diseases of cognitive function.

This work began in 1984 with the discovery that growth factors induce the rapid and transient expression of a family of genes, Immediate Early Genes (IEGs) such as c-fos, whose functions are crucial for neuronal differentiation, cell survival, and adaptive responses (Greenberg and Ziff, 1984). Our recent studies have used more global screening techniques to identify genes whose activity is regulated by stimuli such as membrane depolarization and calcium influx. For example, we recently employed genome-wide sequencing methods to discover thousands of neuronal activity-regulated distal enhancer elements that function in primary cortical cultures, providing new insights into the mechanism of stimulus-dependent enhancer function. From these and other studies we have identified a number of activity-dependent genes that control various processes such as 1) the complexity of the dendritic arbor, 2) the formation, maturation, and maintenance of spines, the post-synaptic sites of excitatory synapses, 3) the composition of protein complexes at the pre- and post-synaptic sites, and 4) the relative number of excitatory and inhibitory synapses. Many disorders of human cognition, including various forms of mental retardation and autism, are correlated with changes in the number of synapses or are believed to be caused by an imbalance between neuronal excitation and inhibition in the nervous system. Thus, understanding how the neuronal activity-dependent gene program functions may provide insight into the molecular mechanisms that govern synaptic development and, ultimately, how the deregulation of this process leads to neurological diseases.

One of our current projects aims to characterize the role of the MeCP2 protein in activity-dependent neuronal responses. MeCP2 binds to methylated CpG DNA sequences and can act as a transcriptional repressor. MECP2 mutations in humans are responsible for >80% of the cases of Rett Syndrome, a childhood neurodevelopmental disorder that shares some characteristics with autism. We have shown that MeCP2 is acutely phosphorylated in response to neuronal activation. Moreover, disruption of MeCP2 phosphorylation in vivo results in defects in synapse development and behavior. In parallel studies, we have also identified Ube3a as a neuronal activity-regulated gene. Loss-of-function mutations in UBE3A give rise to Angelman syndrome, a severe neurodevelopmental disorder characterized by mental retardation and frequent seizures. We have found that Ube3a regulates excitatory synapse development by controlling the degradation of specific neuronal synaptic proteins. Our ongoing investigation of the many molecular players in the activity-regulated gene program should provide new insights into the mechanisms by which neuronal activity shapes the development of the central nervous system.

Our ongoing investigation of the many molecular players in the activity-regulated gene program should provide new insights into the mechanisms by which neuronal activity shapes the development of the central nervous system.

 

Click on the image to see it full-size.Click on the image to see it full-size.

 

  1. Spiegel I, Mardinly AR, Gabel HW, Bazinet JE, Couch CH, Tzeng CP, Harmin DA, Greenberg ME. Npas4 Regulates Excitatory-Inhibitory Balance within Neural Circuits through Cell-Type-Specific Gene Programs. May 22, 2014. Cell.

    Link to Abstract
  2. Deng JV, Wan Y, Wang X, Cohen S, Wetsel WC, Greenberg ME, Kenny PJ, Calakos N, West AE. MeCP2 Phosphorylation Limits Psychostimulant-Induced Behavioral and Neuronal Plasticity. March 26, 2014. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  3. Robichaux MA, Chenaux G, Ho HY, Soskis MJ, Dravis C, Kwan KY, Sestan N, Greenberg ME, Henkemeyer M, Cowan CW. EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding. January 22, 2014. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  4. Bloodgood BL, Sharma N, Browne HA, Trepman AZ, Greenberg ME. The activity-dependent transcription factor NPAS4 regulates domain-specific inhibition. November 7, 2013. Nature.

    Link to Abstract
  5. Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM. Exercise Induces Hippocampal BDNF through a PGC-1a/FNDC5 Pathway. October 10, 2013. Cell metabolism.

    Link to Abstract
  6. Gabel HW, Greenberg ME. Genetics. The maturing brain methylome. August 9, 2013. Science (New York, N.Y.).

    Link to Abstract
  7. Ebert DH, Gabel HW, Robinson ND, Kastan NR, Hu LS, Cohen S, Navarro AJ, Lyst MJ, Ekiert R, Bird AP, Greenberg ME. Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR. July 18, 2013. Nature.

    Link to Abstract
  8. Lyst MJ, Ekiert R, Ebert DH, Merusi C, Nowak J, Selfridge J, Guy J, Kastan NR, Robinson ND, de Lima Alves F, Rappsilber J, Greenberg ME, Bird A. Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor. June 16, 2013. Nature neuroscience.

    Link to Abstract
  9. Veeramah KR, Johnstone L, Karafet TM, Wolf D, Sprissler R, Salogiannis J, Barth-Maron A, Greenberg ME, Stuhlmann T, Weinert S, Jentsch TJ, Pazzi M, Restifo LL, Talwar D, Erickson RP, Hammer MF. Exome sequencing reveals new causal mutations in children with epileptic encephalopathies. May 3, 2013. Epilepsia.

    Link to Abstract
  10. Yu TW, Chahrour MH, Coulter ME, Jiralerspong S, Okamura-Ikeda K, Ataman B, Schmitz-Abe K, Harmin DA, Adli M, Malik AN, D'Gama AM, Lim ET, Sanders SJ, Mochida GH, Partlow JN, Sunu CM, Felie JM, Rodriguez J, Nasir RH, Ware J, Joseph RM, Hill RS, Kwan BY, Al-Saffar M, Mukaddes NM, Hashmi A, Balkhy S, Gascon GG, Hisama FM, LeClair E, Poduri A, Oner O, Al-Saad S, Al-Awadi SA, Bastaki L, Ben-Omran T, Teebi AS, Al-Gazali L, Eapen V, Stevens CR, Rappaport L, Gabriel SB, Markianos K, State MW, Greenberg ME, Taniguchi H, Braverman NE, Morrow EM, Walsh CA. Using whole-exome sequencing to identify inherited causes of autism. January 23, 2013. Neuron.

    Link to Abstract
  11. Ebert DH, Greenberg ME. Activity-dependent neuronal signalling and autism spectrum disorder. January 17, 2013. Nature.

    Link to Abstract
  12. Trauer JM, Bandaranayake D, Booy R, Chen MI, Cretikos M, Dowse GK, Dwyer DE, Greenberg ME, Huang QS, Khandaker G, Kok J, Laurie KL, Lee VJ, McVernon J, Walter S, Markey PG. Seroepidemiologic effects of influenza A(H1N1)pdm09 in Australia, New Zealand, and Singapore. January 1, 2013. Emerging infectious diseases.

    Link to Abstract
  13. Yun J, Nagai T, Furukawa-Hibi Y, Kuroda K, Kaibuchi K, Greenberg ME, Yamada K. Neuronal Per Arnt Sim (PAS) domain protein 4 (NPAS4) regulates neurite outgrowth and phosphorylation of synapsin I. November 21, 2012. The Journal of biological chemistry.

    Link to Abstract
  14. Soskis MJ, Ho HY, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat KM, Sharma N, Cowan CW, Greenberg ME. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. November 11, 2012. Nature neuroscience.

    Link to Abstract
  15. Hemberg M, Gray JM, Cloonan N, Kuersten S, Grimmond S, Greenberg ME, Kreiman G. Integrated genome analysis suggests that most conserved non-coding sequences are regulatory factor binding sites. June 8, 2012. Nucleic acids research.

    Link to Abstract
  16. Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, Ransohoff RM, Greenberg ME, Barres BA, Stevens B. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. May 24, 2012. Neuron.

    Link to Abstract
  17. Chahrour MH, Yu TW, Lim ET, Ataman B, Coulter ME, Hill RS, Stevens CR, Schubert CR, Greenberg ME, Gabriel SB, Walsh CA. Whole-exome sequencing and homozygosity analysis implicate depolarization-regulated neuronal genes in autism. April 12, 2012. PLoS genetics.

    Link to Abstract
  18. Ho HY, Susman MW, Bikoff JB, Ryu YK, Jonas AM, Hu L, Kuruvilla R, Greenberg ME. Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. February 17, 2012. Proceedings of the National Academy of Sciences of the United States of America.

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  19. Wills ZP, Mandel-Brehm C, Mardinly AR, McCord AE, Giger RJ, Greenberg ME. The nogo receptor family restricts synapse number in the developing hippocampus. February 9, 2012. Neuron.

    Link to Abstract
  20. Ross SE, McCord AE, Jung C, Atan D, Mok SI, Hemberg M, Kim TK, Salogiannis J, Hu L, Cohen S, Lin Y, Harrar D, McInnes RR, Greenberg ME. Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. January 26, 2012. Neuron.

    Link to Abstract
  21. Goffin D, Allen M, Zhang L, Amorim M, Wang IT, Reyes AR, Mercado-Berton A, Ong C, Cohen S, Hu L, Blendy JA, Carlson GC, Siegel SJ, Greenberg ME, Zhou Z. Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses. November 27, 2011. Nature neuroscience.

    Link to Abstract
  22. Soskis M, Salogiannis J, Greenberg M. EphrinBs send mixed messages. October 26, 2011. Nature neuroscience.

    Link to Abstract
  23. Cohen S, Gabel HW, Hemberg M, Hutchinson AN, Sadacca LA, Ebert DH, Harmin DA, Greenberg RS, Verdine VK, Zhou Z, Wetsel WC, West AE, Greenberg ME. Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. October 6, 2011. Neuron.

    Link to Abstract
  24. Odajima J, Wills ZP, Ndassa YM, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak S, Quadros IM, Newman J, Das M, Jecrois ME, Yu Q, Li N, Bienvenu F, Moss SJ, Greenberg ME, Marto JA, Sicinski P. Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. September 22, 2011. Developmental cell.

    Link to Abstract
  25. West AE, Greenberg ME. Neuronal activity-regulated gene transcription in synapse development and cognitive function. June 1, 2011. Cold Spring Harbor perspectives in biology.

    Link to Abstract
  26. Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, Mardinly AR, Hu L, Greer PL, Bikoff JB, Ho HY, Soskis MJ, Sahin M, Greenberg ME. EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. October 29, 2010. Cell.

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  27. Kim TK, Hemberg M, Gray JM, Costa AM, Bear DM, Wu J, Harmin DA, Laptewicz M, Barbara-Haley K, Kuersten S, Markenscoff-Papadimitriou E, Kuhl D, Bito H, Worley PF, Kreiman G, Greenberg ME. Widespread transcription at neuronal activity-regulated enhancers. April 14, 2010. Nature.

    Link to Abstract
  28. Ross SE, Mardinly AR, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Greenberg ME. Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. March 25, 2010. Neuron.

    Link to Abstract
  29. Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME. The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. March 5, 2010. Cell.

    Link to Abstract
  30. Cohen S, Greenberg ME. A bird's-eye view of MeCP2 binding. February 26, 2010. Molecular cell.

    Link to Abstract
  31. Shi L, Butt B, Ip FC, Dai Y, Jiang L, Yung WH, Greenberg ME, Fu AK, Ip NY. Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction. January 28, 2010. Neuron.

    Link to Abstract
  32. Greenberg ME, Xu B, Lu B, Hempstead BL. New insights in the biology of BDNF synthesis and release: implications in CNS function. October 14, 2009. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  33. Bracaglia G, Conca B, Bergo A, Rusconi L, Zhou Z, Greenberg ME, Landsberger N, Soddu S, Kilstrup-Nielsen C. Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis. October 9, 2009. EMBO reports.

    Link to Abstract
  34. Wood L, Gray NW, Zhou Z, Greenberg ME, Shepherd GM. Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. October 7, 2009. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  35. Greenberg ME, Smith JD, Sehayek E. Moderately decreased cholesterol absorption rates are associated with a large atheroprotective effect. August 6, 2009. Arteriosclerosis, thrombosis, and vascular biology.

    Link to Abstract
  36. Siegel G, Obernosterer G, Fiore R, Oehmen M, Bicker S, Christensen M, Khudayberdiev S, Leuschner PF, Busch CJ, Kane C, Hübel K, Dekker F, Hedberg C, Rengarajan B, Drepper C, Waldmann H, Kauppinen S, Greenberg ME, Draguhn A, Rehmsmeier M, Martinez J, Schratt GM. A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. May 24, 2009. Nature cell biology.

    Link to Abstract
  37. Pazyra-Murphy MF, Hans A, Courchesne SL, Karch C, Cosker KE, Heerssen HM, Watson FL, Kim T, Greenberg ME, Segal RA. A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w. May 20, 2009. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  38. Fiore R, Khudayberdiev S, Christensen M, Siegel G, Flavell SW, Kim TK, Greenberg ME, Schratt G. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. February 5, 2009. The EMBO journal.

    Link to Abstract
  39. Greer PL, Zieg J, Greenberg ME. Activity-dependent transcription and disorders of human cognition. January 1, 2009. The American journal of psychiatry.

    Link to Abstract
  40. Flavell SW, Kim TK, Gray JM, Harmin DA, Hemberg M, Hong EJ, Markenscoff-Papadimitriou E, Bear DM, Greenberg ME. Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. December 26, 2008. Neuron.

    Link to Abstract
  41. Hong EJ, McCord AE, Greenberg ME. A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. November 26, 2008. Neuron.

    Link to Abstract
  42. Greenberg MJ, Watt JD, Jones M, Kazmierczak K, Szczesna-Cordary D, Moore JR. Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics. September 27, 2008. Journal of molecular and cellular cardiology.

    Link to Abstract
  43. Greer PL, Greenberg ME. From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. September 25, 2008. Neuron.

    Link to Abstract
  44. Lin Y, Bloodgood BL, Hauser JL, Lapan AD, Koon AC, Kim TK, Hu LS, Malik AN, Greenberg ME. Activity-dependent regulation of inhibitory synapse development by Npas4. September 24, 2008. Nature.

    Link to Abstract
  45. Zieg J, Greer PL, Greenberg ME. SnapShot: Ca(2+)-dependent transcription in neurons. September 19, 2008. Cell.

    Link to Abstract
  46. Morrow EM, Yoo SY, Flavell SW, Kim TK, Lin Y, Hill RS, Mukaddes NM, Balkhy S, Gascon G, Hashmi A, Al-Saad S, Ware J, Joseph RM, Greenblatt R, Gleason D, Ertelt JA, Apse KA, Bodell A, Partlow JN, Barry B, Yao H, Markianos K, Ferland RJ, Greenberg ME, Walsh CA. Identifying autism loci and genes by tracing recent shared ancestry. July 11, 2008. Science (New York, N.Y.).

    Link to Abstract
  47. Cohen S, Zhou Z, Greenberg ME. Medicine. Activating a repressor. May 30, 2008. Science (New York, N.Y.).

    Link to Abstract
  48. Kim DS, Ross SE, Trimarchi JM, Aach J, Greenberg ME, Cepko CL. Identification of molecular markers of bipolar cells in the murine retina. April 10, 2008. The Journal of comparative neurology.

    Link to Abstract
  49. Ma YC, Song MR, Park JP, Henry Ho HY, Hu L, Kurtev MV, Zieg J, Ma Q, Pfaff SL, Greenberg ME. Regulation of motor neuron specification by phosphorylation of neurogenin 2. April 10, 2008. Neuron.

    Link to Abstract
  50. Singh KK, Park KJ, Hong EJ, Kramer BM, Greenberg ME, Kaplan DR, Miller FD. Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. April 1, 2008. Nature neuroscience.

    Link to Abstract
  51. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. January 27, 2008. Nature medicine.

    Link to Abstract
  52. Cohen S, Greenberg ME. Communication between the synapse and the nucleus in neuronal development, plasticity, and disease. January 1, 2008. Annual review of cell and developmental biology.

    Link to Abstract
  53. Flavell SW, Greenberg ME. Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. January 1, 2008. Annual review of neuroscience.

    Link to Abstract
  54. Ogier M, Wang H, Hong E, Wang Q, Greenberg ME, Katz DM. Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome. October 3, 2007. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  55. Zhou P, Porcionatto M, Pilapil M, Chen Y, Choi Y, Tolias KF, Bikoff JB, Hong EJ, Greenberg ME, Segal RA. Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. July 5, 2007. Neuron.

    Link to Abstract
  56. Tolias KF, Bikoff JB, Kane CG, Tolias CS, Hu L, Greenberg ME. The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development. April 17, 2007. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  57. Greenberg ME, Bender TP. Identification of newly transcribed RNA. April 1, 2007. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.].

    Link to Abstract
  58. Paradis S, Harrar DB, Lin Y, Koon AC, Hauser JL, Griffith EC, Zhu L, Brass LF, Chen C, Greenberg ME. An RNAi-based approach identifies molecules required for glutamatergic and GABAergic synapse development. January 18, 2007. Neuron.

    Link to Abstract
  59. Fu WY, Chen Y, Sahin M, Zhao XS, Shi L, Bikoff JB, Lai KO, Yung WH, Fu AK, Greenberg ME, Ip NY. Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. December 3, 2006. Nature neuroscience.

    Link to Abstract
  60. Greenberg ME, Sun M, Zhang R, Febbraio M, Silverstein R, Hazen SL. Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells. November 13, 2006. The Journal of experimental medicine.

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  61. Zhou Z, Hong EJ, Cohen S, Zhao WN, Ho HY, Schmidt L, Chen WG, Lin Y, Savner E, Griffith EC, Hu L, Steen JA, Weitz CJ, Greenberg ME. Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. October 19, 2006. Neuron.

    Link to Abstract
  62. Marinescu VD, Kohane IS, Kim TK, Harmin DA, Greenberg ME, Riva A. START: an automated tool for serial analysis of chromatin occupancy data. February 24, 2006. Bioinformatics (Oxford, England).

    Link to Abstract
  63. Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. February 17, 2006. Science (New York, N.Y.).

    Link to Abstract
  64. Ge W, He F, Kim KJ, Blanchi B, Coskun V, Nguyen L, Wu X, Zhao J, Heng JI, Martinowich K, Tao J, Wu H, Castro D, Sobeih MM, Corfas G, Gleeson JG, Greenberg ME, Guillemot F, Sun YE. Coupling of cell migration with neurogenesis by proneural bHLH factors. January 23, 2006. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  65. Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M, Greenberg ME. A brain-specific microRNA regulates dendritic spine development. January 19, 2006. Nature.

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  66. Greenberg ME. Signaling networks that control synapse development and cognitive function. January 1, 2006. Harvey lectures.

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  67. Bhat N, Wright JG, Broder KR, Murray EL, Greenberg ME, Glover MJ, Likos AM, Posey DL, Klimov A, Lindstrom SE, Balish A, Medina MJ, Wallis TR, Guarner J, Paddock CD, Shieh WJ, Zaki SR, Sejvar JJ, Shay DK, Harper SA, Cox NJ, Fukuda K, Uyeki TM. Influenza-associated deaths among children in the United States, 2003-2004. December 15, 2005. The New England journal of medicine.

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  68. Egea J, Nissen UV, Dufour A, Sahin M, Greer P, Kullander K, Mrsic-Flogel TD, Greenberg ME, Kiehn O, Vanderhaeghen P, Klein R. Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. August 18, 2005. Neuron.

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  69. Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, Greenberg ME. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. April 21, 2005. Neuron.

    Link to Abstract
  70. Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME. Vav family GEFs link activated Ephs to endocytosis and axon guidance. April 21, 2005. Neuron.

    Link to Abstract
  71. Tolias KF, Bikoff JB, Burette A, Paradis S, Harrar D, Tavazoie S, Weinberg RJ, Greenberg ME. The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. February 17, 2005. Neuron.

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  72. Hong EJ, West AE, Greenberg ME. Transcriptional control of cognitive development. February 1, 2005. Current opinion in neurobiology.

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  73. Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q. Mouse brain organization revealed through direct genome-scale TF expression analysis. December 24, 2004. Science (New York, N.Y.).

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  74. Schratt GM, Nigh EA, Chen WG, Hu L, Greenberg ME. BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development. August 18, 2004. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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  75. Lu J, Sista P, Giguel F, Greenberg M, Kuritzkes DR. Relative replicative fitness of human immunodeficiency virus type 1 mutants resistant to enfuvirtide (T-20). May 1, 2004. Journal of virology.

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  76. Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. February 19, 2004. Science (New York, N.Y.).

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  77. Chen WG, Chang Q, Lin Y, Meissner A, West AE, Griffith EC, Jaenisch R, Greenberg ME. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. October 31, 2003. Science (New York, N.Y.).

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  78. Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. August 21, 2003. Nature.

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  79. Jünger MA, Rintelen F, Stocker H, Wasserman JD, Végh M, Radimerski T, Greenberg ME, Hafen E. The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. August 7, 2003. Journal of biology.

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  80. Ranger AM, Zha J, Harada H, Datta SR, Danial NN, Gilmore AP, Kutok JL, Le Beau MM, Greenberg ME, Korsmeyer SJ. Bad-deficient mice develop diffuse large B cell lymphoma. July 22, 2003. Proceedings of the National Academy of Sciences of the United States of America.

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  81. Ross SE, Greenberg ME, Stiles CD. Basic helix-loop-helix factors in cortical development. July 3, 2003. Neuron.

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  82. Chen WG, West AE, Tao X, Corfas G, Szentirmay MN, Sawadogo M, Vinson C, Greenberg ME. Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. April 1, 2003. The Journal of neuroscience : the official journal of the Society for Neuroscience.

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  83. Tran H, Brunet A, Griffith EC, Greenberg ME. The many forks in FOXO's road. March 4, 2003. Science's STKE : signal transduction knowledge environment.

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  84. West AE, Griffith EC, Greenberg ME. Regulation of transcription factors by neuronal activity. December 1, 2002. Nature reviews. Neuroscience.

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  85. Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, Cowan CW, Dikkes P, Korsmeyer SJ, Greenberg ME. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. November 1, 2002. Developmental cell.

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  86. Spotts JM, Dolmetsch RE, Greenberg ME. Time-lapse imaging of a dynamic phosphorylation-dependent protein-protein interaction in mammalian cells. November 1, 2002. Proceedings of the National Academy of Sciences of the United States of America.

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  87. Shaywitz AJ, Dove SL, Greenberg ME, Hochschild A. Analysis of phosphorylation-dependent protein-protein interactions using a bacterial two-hybrid system. July 23, 2002. Science's STKE : signal transduction knowledge environment.

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  88. Humbert S, Bryson EA, Cordelières FP, Connors NC, Datta SR, Finkbeiner S, Greenberg ME, Saudou F. The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. June 1, 2002. Developmental cell.

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  89. Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ, DiStefano PS, Chiang LW, Greenberg ME. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. April 19, 2002. Science (New York, N.Y.).

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  90. Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg ME. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. April 11, 2002. Neuron.

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  91. Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. February 25, 2002. The Journal of cell biology.

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  92. Tao X, West AE, Chen WG, Corfas G, Greenberg ME. A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. January 31, 2002. Neuron.

    Link to Abstract
  93. Takasu MA, Dalva MB, Zigmond RE, Greenberg ME. Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. December 20, 2001. Science (New York, N.Y.).

    Link to Abstract
  94. Masters SC, Yang H, Datta SR, Greenberg ME, Fu H. 14-3-3 inhibits Bad-induced cell death through interaction with serine-136. December 1, 2001. Molecular pharmacology.

    Link to Abstract
  95. Murga M, Fernández-Capetillo O, Field SJ, Moreno B, Borlado LR, Fujiwara Y, Balomenos D, Vicario A, Carrera AC, Orkin SH, Greenberg ME, Zubiaga AM. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity. December 1, 2001. Immunity.

    Link to Abstract
  96. Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G. The E2F1-3 transcription factors are essential for cellular proliferation. November 22, 2001. Nature.

    Link to Abstract
  97. Dolmetsch RE, Pajvani U, Fife K, Spotts JM, Greenberg ME. Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. October 12, 2001. Science (New York, N.Y.).

    Link to Abstract
  98. Morishima Y, Gotoh Y, Zieg J, Barrett T, Takano H, Flavell R, Davis RJ, Shirasaki Y, Greenberg ME. Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand. October 1, 2001. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  99. West AE, Chen WG, Dalva MB, Dolmetsch RE, Kornhauser JM, Shaywitz AJ, Takasu MA, Tao X, Greenberg ME. Calcium regulation of neuronal gene expression. September 25, 2001. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  100. Griffith EC, Cowan CW, Greenberg ME. REST acts through multiple deacetylase complexes. August 16, 2001. Neuron.

    Link to Abstract
  101. Leone G, Sears R, Huang E, Rempel R, Nuckolls F, Park CH, Giangrande P, Wu L, Saavedra HI, Field SJ, Thompson MA, Yang H, Fujiwara Y, Greenberg ME, Orkin S, Smith C, Nevins JR. Myc requires distinct E2F activities to induce S phase and apoptosis. July 1, 2001. Molecular cell.

    Link to Abstract
  102. Zhang BH, Tang ED, Zhu T, Greenberg ME, Vojtek AB, Guan KL. Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. June 15, 2001. The Journal of biological chemistry.

    Link to Abstract
  103. Brunet A, Datta SR, Greenberg ME. Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. June 1, 2001. Current opinion in neurobiology.

    Link to Abstract
  104. Dudek H, Ghosh A, Greenberg ME. Calcium phosphate transfection of DNA into neurons in primary culture. May 1, 2001. Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.].

    Link to Abstract
  105. Shamah SM, Lin MZ, Goldberg JL, Estrach S, Sahin M, Hu L, Bazalakova M, Neve RL, Corfas G, Debant A, Greenberg ME. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. April 20, 2001. Cell.

    Link to Abstract
  106. Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. February 9, 2001. Cell.

    Link to Abstract
  107. Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). February 1, 2001. Molecular and cellular biology.

    Link to Abstract
  108. Dalva MB, Takasu MA, Lin MZ, Shamah SM, Hu L, Gale NW, Greenberg ME. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. December 8, 2000. Cell.

    Link to Abstract
  109. Shaywitz AJ, Dove SL, Kornhauser JM, Hochschild A, Greenberg ME. Magnitude of the CREB-dependent transcriptional response is determined by the strength of the interaction between the kinase-inducible domain of CREB and the KIX domain of CREB-binding protein. December 1, 2000. Molecular and cellular biology.

    Link to Abstract
  110. Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. July 1, 2000. Molecular cell.

    Link to Abstract
  111. Lin MZ, Greenberg ME. Orchestral maneuvers in the axon: trio and the control of axon guidance. April 28, 2000. Cell.

    Link to Abstract
  112. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. November 15, 1999. Genes & development.

    Link to Abstract
  113. Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. November 12, 1999. Science (New York, N.Y.).

    Link to Abstract
  114. Mao Z, Bonni A, Xia F, Nadal-Vicens M, Greenberg ME. Neuronal activity-dependent cell survival mediated by transcription factor MEF2. October 22, 1999. Science (New York, N.Y.).

    Link to Abstract
  115. Lock M, Greenberg ME, Iafrate AJ, Swigut T, Muench J, Kirchhoff F, Shohdy N, Skowronski J. Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis. May 17, 1999. The EMBO journal.

    Link to Abstract
  116. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. March 19, 1999. Cell.

    Link to Abstract
  117. Shaywitz AJ, Greenberg ME. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. January 1, 1999. Annual review of biochemistry.

    Link to Abstract
  118. Sekiguchi JM, Gao Y, Gu Y, Frank K, Sun Y, Chaudhuri J, Zhu C, Cheng HL, Manis J, Ferguson D, Davidson L, Greenberg ME, Alt FW. Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis. January 1, 1999. Cold Spring Harbor symposia on quantitative biology.

    Link to Abstract
  119. Skowronski J, Greenberg ME, Lock M, Mariani R, Salghetti S, Swigut T, Iafrate AJ. HIV and SIV Nef modulate signal transduction and protein sorting in T cells. January 1, 1999. Cold Spring Harbor symposia on quantitative biology.

    Link to Abstract
  120. Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH, Greenberg ME, Alt FW. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. December 23, 1998. Cell.

    Link to Abstract
  121. Saudou F, Finkbeiner S, Devys D, Greenberg ME. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. October 2, 1998. Cell.

    Link to Abstract
  122. Finkbeiner S, Greenberg ME. Ca2+ channel-regulated neuronal gene expression. October 1, 1998. Journal of neurobiology.

    Link to Abstract
  123. Hiroi N, Marek GJ, Brown JR, Ye H, Saudou F, Vaidya VA, Duman RS, Greenberg ME, Nestler EJ. Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures. September 1, 1998. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  124. Brown JR, Nigh E, Lee RJ, Ye H, Thompson MA, Saudou F, Pestell RG, Greenberg ME. Fos family members induce cell cycle entry by activating cyclin D1. September 1, 1998. Molecular and cellular biology.

    Link to Abstract
  125. Xing J, Kornhauser JM, Xia Z, Thiele EA, Greenberg ME. Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation. April 1, 1998. Molecular and cellular biology.

    Link to Abstract
  126. Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME. Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. April 1, 1998. Neuron.

    Link to Abstract
  127. Greenberg ME, Mathews MB. Effects of heterologous downstream sequences on the activity of the HIV-1 promoter and its response to Tat. December 15, 1997. Nucleic acids research.

    Link to Abstract
  128. Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME. CREB: a major mediator of neuronal neurotrophin responses. November 1, 1997. Neuron.

    Link to Abstract
  129. Bonni A, Greenberg ME. Neurotrophin regulation of gene expression. November 1, 1997. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.

    Link to Abstract
  130. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. October 17, 1997. Cell.

    Link to Abstract
  131. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. October 17, 1997. Science (New York, N.Y.).

    Link to Abstract
  132. Hiroi N, Brown JR, Haile CN, Ye H, Greenberg ME, Nestler EJ. FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. September 16, 1997. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  133. Greenberg ME, Ostapenko DA, Mathews MB. Potentiation of human immunodeficiency virus type 1 Tat by human cellular proteins. September 1, 1997. Journal of virology.

    Link to Abstract
  134. Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, Davis RJ. A cytoplasmic inhibitor of the JNK signal transduction pathway. August 1, 1997. Science (New York, N.Y.).

    Link to Abstract
  135. Finkbeiner S, Greenberg ME. Spatial features of calcium-regulated gene expression. August 1, 1997. BioEssays : news and reviews in molecular, cellular and developmental biology.

    Link to Abstract
  136. Kornhauser JM, Greenberg ME. A kinase to remember: dual roles for MAP kinase in long-term memory. June 1, 1997. Neuron.

    Link to Abstract
  137. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME. Regulation of neuronal survival by the serine-threonine protein kinase Akt. January 31, 1997. Science (New York, N.Y.).

    Link to Abstract
  138. Xia Z, Dudek H, Miranti CK, Greenberg ME. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. September 1, 1996. The Journal of neuroscience : the official journal of the Society for Neuroscience.

    Link to Abstract
  139. Xing J, Ginty DD, Greenberg ME. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. August 16, 1996. Science (New York, N.Y.).

    Link to Abstract
  140. Brown JR, Ye H, Bronson RT, Dikkes P, Greenberg ME. A defect in nurturing in mice lacking the immediate early gene fosB. July 26, 1996. Cell.

    Link to Abstract
  141. Field SJ, Tsai FY, Kuo F, Zubiaga AM, Kaelin WG, Livingston DM, Orkin SH, Greenberg ME. E2F-1 functions in mice to promote apoptosis and suppress proliferation. May 17, 1996. Cell.

    Link to Abstract
  142. Rosen LB, Greenberg ME. Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels. February 6, 1996. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  143. Finkbeiner S, Greenberg ME. Ca(2+)-dependent routes to Ras: mechanisms for neuronal survival, differentiation, and plasticity? February 1, 1996. Neuron.

    Link to Abstract
  144. Kornhauser JM, Ginty DD, Greenberg ME, Mayo KE, Takahashi JS. Light entrainment and activation of signal transduction pathways in the SCN. January 1, 1996. Progress in brain research.

    Link to Abstract
  145. Segal RA, Greenberg ME. Intracellular signaling pathways activated by neurotrophic factors. January 1, 1996. Annual review of neuroscience.

    Link to Abstract
  146. Frank DA, Greenberg ME. Signal transduction pathways activated by ciliary neurotrophic factor and related cytokines. January 1, 1996. Perspectives on developmental neurobiology.

    Link to Abstract
  147. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. November 24, 1995. Science (New York, N.Y.).

    Link to Abstract
  148. Hirata Y, Whalin M, Ginty DD, Xing J, Greenberg ME, Milbrandt J, Guroff G. Induction of a nerve growth factor-sensitive kinase that phosphorylates the DNA-binding domain of the orphan nuclear receptor NGFI-B. October 1, 1995. Journal of neurochemistry.

    Link to Abstract
  149. Frank DA, Robertson MJ, Bonni A, Ritz J, Greenberg ME. Interleukin 2 signaling involves the phosphorylation of Stat proteins. August 15, 1995. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  150. Farnsworth CL, Freshney NW, Rosen LB, Ghosh A, Greenberg ME, Feig LA. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. August 10, 1995. Nature.

    Link to Abstract
  151. Ghosh A, Greenberg ME. Distinct roles for bFGF and NT-3 in the regulation of cortical neurogenesis. July 1, 1995. Neuron.

    Link to Abstract
  152. Miranti CK, Ginty DD, Huang G, Chatila T, Greenberg ME. Calcium activates serum response factor-dependent transcription by a Ras- and Elk-1-independent mechanism that involves a Ca2+/calmodulin-dependent kinase. July 1, 1995. Molecular and cellular biology.

    Link to Abstract
  153. Gallin WJ, Greenberg ME. Calcium regulation of gene expression in neurons: the mode of entry matters. June 1, 1995. Current opinion in neurobiology.

    Link to Abstract
  154. Ghosh A, Greenberg ME. Calcium signaling in neurons: molecular mechanisms and cellular consequences. April 14, 1995. Science (New York, N.Y.).

    Link to Abstract
  155. Zubiaga AM, Belasco JG, Greenberg ME. The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. April 1, 1995. Molecular and cellular biology.

    Link to Abstract
  156. Bonni A, Ginty DD, Dudek H, Greenberg ME. Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals. April 1, 1995. Molecular and cellular neurosciences.

    Link to Abstract
  157. Thompson MA, Ginty DD, Bonni A, Greenberg ME. L-type voltage-sensitive Ca2+ channel activation regulates c-fos transcription at multiple levels. March 3, 1995. The Journal of biological chemistry.

    Link to Abstract
  158. Bading H, Segal MM, Sucher NJ, Dudek H, Lipton SA, Greenberg ME. N-methyl-D-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons. February 1, 1995. Neuroscience.

    Link to Abstract
  159. Rosen LB, Ginty DD, Greenberg ME. Calcium regulation of gene expression. January 1, 1995. Advances in second messenger and phosphoprotein research.

    Link to Abstract
  160. Misra RP, Bonni A, Miranti CK, Rivera VM, Sheng M, Greenberg ME. L-type voltage-sensitive calcium channel activation stimulates gene expression by a serum response factor-dependent pathway. October 14, 1994. The Journal of biological chemistry.

    Link to Abstract
  161. Frank DA, Greenberg ME. CREB: a mediator of long-term memory from mollusks to mammals. October 7, 1994. Cell.

    Link to Abstract
  162. Ginty DD, Bonni A, Greenberg ME. Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. June 3, 1994. Cell.

    Link to Abstract
  163. Rosen LB, Ginty DD, Weber MJ, Greenberg ME. Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. June 1, 1994. Neuron.

    Link to Abstract
  164. Ghosh A, Carnahan J, Greenberg ME. Requirement for BDNF in activity-dependent survival of cortical neurons. March 18, 1994. Science (New York, N.Y.).

    Link to Abstract
  165. Ghosh A, Ginty DD, Bading H, Greenberg ME. Calcium regulation of gene expression in neuronal cells. March 1, 1994. Journal of neurobiology.

    Link to Abstract
  166. Schiavi SC, Wellington CL, Shyu AB, Chen CY, Greenberg ME, Belasco JG. Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation. February 4, 1994. The Journal of biological chemistry.

    Link to Abstract
  167. Bonni A, Frank DA, Schindler C, Greenberg ME. Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus. December 3, 1993. Science (New York, N.Y.).

    Link to Abstract
  168. Sucher NJ, Brose N, Deitcher DL, Awobuluyi M, Gasic GP, Bading H, Cepko CL, Greenberg ME, Jahn R, Heinemann SF. Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells. October 25, 1993. The Journal of biological chemistry.

    Link to Abstract
  169. Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. October 1, 1993. Molecular and cellular biology.

    Link to Abstract
  170. Wellington CL, Greenberg ME, Belasco JG. The destabilizing elements in the coding region of c-fos mRNA are recognized as RNA. August 1, 1993. Molecular and cellular biology.

    Link to Abstract
  171. Bading H, Ginty DD, Greenberg ME. Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. April 9, 1993. Science (New York, N.Y.).

    Link to Abstract
  172. Ginty DD, Kornhauser JM, Thompson MA, Bading H, Mayo KE, Takahashi JS, Greenberg ME. Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. April 9, 1993. Science (New York, N.Y.).

    Link to Abstract
  173. Liu F, Thompson MA, Wagner S, Greenberg ME, Green MR. Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation. March 25, 1993. The Journal of biological chemistry.

    Link to Abstract
  174. Schiavi SC, Belasco JG, Greenberg ME. Regulation of proto-oncogene mRNA stability. December 16, 1992. Biochimica et biophysica acta.

    Link to Abstract
  175. Field SJ, Johnson RS, Mortensen RM, Papaioannou VE, Spiegelman BM, Greenberg ME. Growth and differentiation of embryonic stem cells that lack an intact c-fos gene. October 1, 1992. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  176. Ginty DD, Bading H, Greenberg ME. Trans-synaptic regulation of gene expression. June 1, 1992. Current opinion in neurobiology.

    Link to Abstract
  177. Guitart X, Thompson MA, Mirante CK, Greenberg ME, Nestler EJ. Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus. March 1, 1992. Journal of neurochemistry.

    Link to Abstract
  178. Greenberg ME, Thompson MA, Sheng M. Calcium regulation of immediate early gene transcription. January 1, 1992. Journal of physiology, Paris.

    Link to Abstract
  179. Misra RP, Rivera VM, Wang JM, Fan PD, Greenberg ME. The serum response factor is extensively modified by phosphorylation following its synthesis in serum-stimulated fibroblasts. September 1, 1991. Molecular and cellular biology.

    Link to Abstract
  180. Bading H, Greenberg ME. Stimulation of protein tyrosine phosphorylation by NMDA receptor activation. August 23, 1991. Science (New York, N.Y.).

    Link to Abstract
  181. Sheng M, Thompson MA, Greenberg ME. CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. June 7, 1991. Science (New York, N.Y.).

    Link to Abstract
  182. Hazel TG, Misra R, Davis IJ, Greenberg ME, Lau LF. Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment. June 1, 1991. Molecular and cellular biology.

    Link to Abstract
  183. Shyu AB, Belasco JG, Greenberg ME. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. February 1, 1991. Genes & development.

    Link to Abstract
  184. Rivera VM, Greenberg ME. Growth factor-induced gene expression: the ups and downs of c-fos regulation. September 1, 1990. The New biologist.

    Link to Abstract
  185. Sheng M, Greenberg ME. The regulation and function of c-fos and other immediate early genes in the nervous system. April 1, 1990. Neuron.

    Link to Abstract
  186. Sheng M, McFadden G, Greenberg ME. Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. April 1, 1990. Neuron.

    Link to Abstract
  187. Rivera VM, Sheng M, Greenberg ME. The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation. February 1, 1990. Genes & development.

    Link to Abstract
  188. Greenberg ME, Shyu AB, Belasco JG. Deadenylylation: a mechanism controlling c-fos mRNA decay. January 1, 1990. Enzyme.

    Link to Abstract
  189. Johnson RS, Sheng M, Greenberg ME, Kolodner RD, Papaioannou VE, Spiegelman BM. Targeting of nonexpressed genes in embryonic stem cells via homologous recombination. September 15, 1989. Science (New York, N.Y.).

    Link to Abstract
  190. Bartel DP, Sheng M, Lau LF, Greenberg ME. Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction. March 1, 1989. Genes & development.

    Link to Abstract
  191. Shyu AB, Greenberg ME, Belasco JG. The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. January 1, 1989. Genes & development.

    Link to Abstract
  192. Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. December 2, 1988. Cell.

    Link to Abstract
  193. Sheng M, Dougan ST, McFadden G, Greenberg ME. Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences. July 1, 1988. Molecular and cellular biology.

    Link to Abstract
  194. Greenberg ME, Siegfried Z, Ziff EB. Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro. March 1, 1987. Molecular and cellular biology.

    Link to Abstract
  195. Nepveu A, Levine RA, Campisi J, Greenberg ME, Ziff EB, Marcu KB. Alternative modes of c-myc regulation in growth factor-stimulated and differentiating cells. January 1, 1987. Oncogene.

    Link to Abstract
  196. Greenberg ME, Ziff EB, Greene LA. Stimulation of neuronal acetylcholine receptors induces rapid gene transcription. October 3, 1986. Science (New York, N.Y.).

    Link to Abstract
  197. Greenberg ME, Hermanowski AL, Ziff EB. Effect of protein synthesis inhibitors on growth factor activation of c-fos, c-myc, and actin gene transcription. April 1, 1986. Molecular and cellular biology.

    Link to Abstract
  198. Greenberg ME, Greene LA, Ziff EB. Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. November 15, 1985. The Journal of biological chemistry.

    Link to Abstract
  199. Antler AM, Greenberg ME, Edelman GM, Hanafusa H. Increased phosphorylation of tyrosine in vinculin does not occur upon transformation by some avian sarcoma viruses. January 1, 1985. Molecular and cellular biology.

    Link to Abstract
  200. Greenberg ME, Ziff EB. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. October 1, 1984. Nature.

    Link to Abstract
  201. Greenberg ME, Brackenbury R, Edelman GM. Alteration of neural cell adhesion molecule (N-CAM) expression after neuronal cell transformation by Rous sarcoma virus. February 1, 1984. Proceedings of the National Academy of Sciences of the United States of America.

    Link to Abstract
  202. Greenberg ME, Brackenbury R, Edelman GM. Changes in the distribution of the 34-kdalton tyrosine kinase substrate during differentiation and maturation of chicken tissues. February 1, 1984. The Journal of cell biology.

    Link to Abstract
  203. Greenberg ME, Edelman GM. Comparison of the 34,000-Da pp60src substrate and a 38,000-Da phosphoprotein identified by monoclonal antibodies. July 10, 1983. The Journal of biological chemistry.

    Link to Abstract
  204. Greenberg ME, Edelman GM. The 34 kd pp60src substrate is located at the inner face of the plasma membrane. July 1, 1983. Cell.

    Link to Abstract
  205. Edelman GM, Hoffman S, Chuong CM, Thiery JP, Brackenbury R, Gallin WJ, Grumet M, Greenberg ME, Hemperly JJ, Cohen C. Structure and modulation of neural cell adhesion molecules in early and late embryogenesis. January 1, 1983. Cold Spring Harbor symposia on quantitative biology.

    Link to Abstract
  206. Maness PF, Engeser H, Greenberg ME, O'Farrell M, Gall WE, Edelman GM. Activities of the src-gene product of avian sarcoma virus. January 1, 1980. Cold Spring Harbor symposia on quantitative biology.

    Link to Abstract

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